Kirksville College of Osteopathic Medicine
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Faculty and Staff

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The department of physiology



William F. Brechue, PhD, Professor and Chair
Robert W. Baer, PhD, Professor
Timothy P. Geisbuhler, PhD, Associate Professor
William L. Sexton, PhD
, Professor
Yohei Norimatsu, PhD, Assistant Professor
Tim D. Ostrowski, PhD, Assistant Professor

D. Fred Peterson, PhD, Emeritus Professor

Malford Cullum, PhD, Adjunct Instructor
Mary Beth Regan, PhD, RN, CNS, CWCN, Adjunct Instructor
Ginger D. Salvadalena, PhD, Adjunct Instructor
Michael Taylor, PhD, Adjunct Instructor
*Each person's name is linked to biographical data and publications. Activity for all ATSU/KCOM faculty by year (publications, presentations, funding and honors) can be accessed at Scholarly Activity.

physiology DEpartment Staff

Jan Dabney, Administrative Assistant
Bonnie King, Technician

courses directed by department Faculty*

DO Program Courses (Course Directors):
Medical Physiology I, II, III (Dr. W. Sexton)

MOSDOH Program Courses (Course Directors)
Neuroregulatory Systems (Dr. Towns, Anatomy Dept.)
Musculoskeletal-Integument Systems (Dr. Brechue)
Cardiopulmonary Systems (Dr. Brechue)
Urinary-Renal System (Dr. Sexton)
Reproductive System (Dr. Geisbuhler)
Gastrointestinal System (Dr. Norimatsu)

Unique Courses in the Biomedical Sciences Program (Course Directors):
Critical Reading for Biomedical Sciences (Dr. W. Sexton)
Ethics in Biomedical Research (Dr. W. Sexton)
Grant Writing (Dr. W. Sexton)
Introduction to Research Design (Dr. W. Sexton)
Research, Design and Biostatistics (Dr. W. Sexton)
*Each course is described in the ATSU-KCOM College Catalog.

Teaching Assignments and On-going Research Projects

Dr. Brechue teaches in Medical Physiology and MOSDOH Musculoskeletal-Integument and Cardiopulmonary Systems. His research interests involve the following studies, which are conducted in the general population, athletes, elderly, and end-stage disease:

  • Musculoskeletal and neuromuscular aspects of human movement and fatigue
  • Structure-function asymmetry and variability in basic human movement and in    injury/surgery and rehabilitation
  • Role of posture and balance in physical function
  • Cardiopulmonary determinants of physical function
  • Determinants of muscular strength, power and running speed

Dr. Baer teaches in Medical Physiology and MOSDOH Cardiopulmonary Systems. His research interests involve the following topics:

  • Mechanisms underlying the anti-metastatic actions of caveolin-1 in melanoma

  • Role of chemokine signaling in metastatic behavior of melanoma (migration, invasion, adhesion, proliferation, and apoptosis)
  • Signaling in vascular and vascular-like network formation (angiogenesis
    and vasculogenic mimicry)

Dr. Geisbuhler teaches in Medical Physiology and MOSDOH Neuroregulatory and Reproductive Systems. His research interests involve the following topics:

  • Protection of ischemic/anoxic heart by estrogen, phytoestrogens and other natural products

  • Nucleotide metabolism in ischemic and anoxic heart cells (bioenergetics)
  • Impact of plant natural products (“botanicals”) on cardiac function and cardiac cell metabolism

Dr. Norimatsu teaches in Medical Physiology and MOSDOH Gastrointestinal Systems. His research interests involve the following topics:

  • Electrophysiological characterization of cystic fibrosis
  • Transmembrane Conductance Regulator (CFTR) channel with the use of chemical modification
  • Functional study of drug-receptor interactions
  • Atomic-scale molecular modeling. virtual ligand docking, molecular dynamics simulation

Dr. Sexton teaches in Medical Physiology and MOSDOH Cardiopulmonary and Urinary-Renal Systems. His research interests involve the following topics:

  • Determinants of oxygen delivery in the microcirculation of skeletal muscle, heart and diaphragm with emphasis on the impact of exercise training, diabetes, aging, and hypertension
  • mpact of peripheral vascular flow impairment on oxygen delivery and muscle function, and the role of collateral vessel formation, in health, diabetes, and exercise training
  • Role of nitric oxide in the control of oxygen delivery and utilization in contracting skeletal muscle, diaphragm and heart and interactions with disease and aging
    Impact of statins on skeletal muscle function and microvascular oxygen kinetics
  • Diaphragm function in health and disease (e.g., emphysema and diabetes)
  • Molecular mechanisms of angiogenesis in skeletal muscle, diaphragm and heart

Drs. Cullum, Regan, Salvadalena, and Taylor are researchers at Hollister Inc., and collaborate with this department under their adjunct appointments and in connection with the annual Hollister-KCOM Clinical Research Fellowship Program.