Rick Fleschner, PhD
Professor and Chair
Work: 660.626.2348
Fax: 660.626.2981
Fax: 660.626.2981
Email Address: cfleschner@atsu.edu
Research Interests: Dr. Fleschner's research interests are describing the structure and function of ocular lens plasma membranes and describing biochemical changes which occur in the composition of these plasma membranes during the formation of experimental cataracts. This knowledge will be useful in the understanding of human senile cataracts.
Education:
PhD - University of Missouri - Columbia (1983)Scholarly Activity
Research Publications:
2013 |
Whitman JK, Alviar AF, Fleschner CR, Stuart MK. Monoclonal antibody 10A5 recognizes an antigen unique to the water-insoluble 25/45 membrane fraction of the rat ocular lens. SpringerPlus 2013 Oct 2;2:500;13pp. doi:10.1186/2193-1801-2-500
2005 | Fleschner CR. Connexin 46 and connexin 50 in selenite cataract. Ophthalmic Res. 2006;38(1):24-8. Epub 2005 Sep 26
2003 | Brooks J, Fleschner CR. Identification of a vimentin-reactive Peptide associated with ocular lens membranes as cytokeratin. Ophthalmic Res. 2003;35(1):8-11
2002 | Fleschner CR. Lens membrane fraction associated intermediate filaments of different aged rats. Curr Eye Res 2002 Apr;24(4):296-304
1998 | Fleschner CR. Intermediate filament cytoskeletal proteins associated with bovine lens native membrane fractions. Curr Eye Res 1998 Apr;17(4):409-18
1997 | Fleschner CR, Cenedella RJ. Neutral lipids of the plasma membrane: composition of plasma membrane fractions isolated from ocular lens. Curr Eye Res 1997 Mar;16(3):263-9
1993 | Fleschner CR, Cenedella RJ. Isolation of a non-sedimenting membrane fraction from the water soluble fraction of bovine lens. Exp Eye Res 1993 Jun;56(6):649-57
1992 | Cenedella RJ, Fleschner CR. Selective association of crystallins with lens 'native' membrane during dynamic cataractogenesis. Curr Eye Res 1992 Aug;11(8):801-15
1992 | Fleschner CR, Cenedella RJ. Examination of a lens 'native' plasma membrane fraction and its associated crystallins. Curr Eye Res 1992 Aug;11(8):739-52
1991 | Fleschner CR, Cenedella RJ. Lipid composition of lens plasma membrane fractions enriched in fiber junctions. J Lipid Res 1991 Jan;32(1):45-53
1990 | Cenedella RJ, Fleschner CR. Kinetics of corneal epithelium turnover in vivo. Studies of lovastatin. Invest Ophthalmol Vis Sci 1990 Oct;31(10):1957-62
1990 | Kraus-Friedmann N, Higham S, Fleschner CR. Hormonal stimulation of Ca2+ release from the perfused liver: effects of uncoupler. Am J Physiol 1990 Jan;258(1 Pt 1):G73-7
1989 | Cenedella RJ, Fleschner CR. Cholesterol biosynthesis by the cornea. Comparison of rates of sterol synthesis with accumulation during early development. J Lipid Res 1989 Jul;30(7):1079-84
1988 | Kraus-Friedmann N, Fleschner CR, Zimniak P, Moore P. The hepatic microsomal Ca2+ sequestering system. Adv Exp Med Biol 1988;232:59-68
1988 | Fleschner CR, Cenedella RJ. Specific restriction of cholesterol from cortical lens gap junctional membrane in the U18666A cataract. Curr Eye Res 1988 Oct;7(10):1029-34
1987 | Fleschner CR, Kraus-Friedmann N. Inhibition of rat liver microsomal Ca2+-ATPase by fluorescein-5'-isothiocyanate. Arch Biochem Biophys 1987 May 1;254(2):448-53
1986 | Fleschner CR, Kraus-Friedmann N. The effect of Mg2+ on hepatic microsomal Ca2+ and Sr2+ transport. Eur J Biochem 1986 Jan 15;154(2):313-20
1985 | Fleschner CR, Kraus-Friedmann N, Wibert GJ. Phosphorylated intermediates of two hepatic microsomal ATPases. Biochem J 1985 Mar 15;226(3):839-45
1983 | Fleschner CR, Martin AP, Vorbeck ML, Darnold JR, Long JW Jr. Ca2+ release from energetically coupled tumor mitochondria. Biochem Biophys Res Commun 1983 Sep 15;115(2):430-6
1982 | Fleschner CR, Pershadsingh HA, Vorbeck ML, Long JW Jr, Martin AP. Phosphate-dependent, trifluoperazine-sensitive Ca2+ efflux from rat liver mitochondria. Modulation by a cytosol factor. FEBS Lett 1982 May 3;141(1):45-8
2005 | Fleschner CR. Connexin 46 and connexin 50 in selenite cataract. Ophthalmic Res. 2006;38(1):24-8. Epub 2005 Sep 26
2003 | Brooks J, Fleschner CR. Identification of a vimentin-reactive Peptide associated with ocular lens membranes as cytokeratin. Ophthalmic Res. 2003;35(1):8-11
2002 | Fleschner CR. Lens membrane fraction associated intermediate filaments of different aged rats. Curr Eye Res 2002 Apr;24(4):296-304
1998 | Fleschner CR. Intermediate filament cytoskeletal proteins associated with bovine lens native membrane fractions. Curr Eye Res 1998 Apr;17(4):409-18
1997 | Fleschner CR, Cenedella RJ. Neutral lipids of the plasma membrane: composition of plasma membrane fractions isolated from ocular lens. Curr Eye Res 1997 Mar;16(3):263-9
1993 | Fleschner CR, Cenedella RJ. Isolation of a non-sedimenting membrane fraction from the water soluble fraction of bovine lens. Exp Eye Res 1993 Jun;56(6):649-57
1992 | Cenedella RJ, Fleschner CR. Selective association of crystallins with lens 'native' membrane during dynamic cataractogenesis. Curr Eye Res 1992 Aug;11(8):801-15
1992 | Fleschner CR, Cenedella RJ. Examination of a lens 'native' plasma membrane fraction and its associated crystallins. Curr Eye Res 1992 Aug;11(8):739-52
1991 | Fleschner CR, Cenedella RJ. Lipid composition of lens plasma membrane fractions enriched in fiber junctions. J Lipid Res 1991 Jan;32(1):45-53
1990 | Cenedella RJ, Fleschner CR. Kinetics of corneal epithelium turnover in vivo. Studies of lovastatin. Invest Ophthalmol Vis Sci 1990 Oct;31(10):1957-62
1990 | Kraus-Friedmann N, Higham S, Fleschner CR. Hormonal stimulation of Ca2+ release from the perfused liver: effects of uncoupler. Am J Physiol 1990 Jan;258(1 Pt 1):G73-7
1989 | Cenedella RJ, Fleschner CR. Cholesterol biosynthesis by the cornea. Comparison of rates of sterol synthesis with accumulation during early development. J Lipid Res 1989 Jul;30(7):1079-84
1988 | Kraus-Friedmann N, Fleschner CR, Zimniak P, Moore P. The hepatic microsomal Ca2+ sequestering system. Adv Exp Med Biol 1988;232:59-68
1988 | Fleschner CR, Cenedella RJ. Specific restriction of cholesterol from cortical lens gap junctional membrane in the U18666A cataract. Curr Eye Res 1988 Oct;7(10):1029-34
1987 | Fleschner CR, Kraus-Friedmann N. Inhibition of rat liver microsomal Ca2+-ATPase by fluorescein-5'-isothiocyanate. Arch Biochem Biophys 1987 May 1;254(2):448-53
1986 | Fleschner CR, Kraus-Friedmann N. The effect of Mg2+ on hepatic microsomal Ca2+ and Sr2+ transport. Eur J Biochem 1986 Jan 15;154(2):313-20
1985 | Fleschner CR, Kraus-Friedmann N, Wibert GJ. Phosphorylated intermediates of two hepatic microsomal ATPases. Biochem J 1985 Mar 15;226(3):839-45
1983 | Fleschner CR, Martin AP, Vorbeck ML, Darnold JR, Long JW Jr. Ca2+ release from energetically coupled tumor mitochondria. Biochem Biophys Res Commun 1983 Sep 15;115(2):430-6
1982 | Fleschner CR, Pershadsingh HA, Vorbeck ML, Long JW Jr, Martin AP. Phosphate-dependent, trifluoperazine-sensitive Ca2+ efflux from rat liver mitochondria. Modulation by a cytosol factor. FEBS Lett 1982 May 3;141(1):45-8
Books, Chapters, and Reviews:
1986 |
Fleschner CR, Kraus-Friedmann N. 1986. Hormonal effects on the microsomal Ca2+-ATPase. In: Hormonal Regulation of Gluconeogenesis Volume II (N. Kraus-Friedmann, ed), CRC Press, Boca Raton, FL.
Presentations and Published Abstracts:
2015 |
Whitman JK [resident], Alviar AF, Fleschner CR, Stuart MK. Monoclonal Antibody 10A5 Recognizes an Antigen Unique to the Water-Insoluble 25/45 Fraction of the Rat Ocular Lens. Poster presented at 99th Annual Clinical Assembly of the American Osteopathic Colleges of Ophthalmology and Otolaryngology-Head and Neck Surgery Foundation, Inc., Orlando, FL; May 6-10, 2015
2014 | Foreman M [student], Fleschner C. The Role of Vimentin, Filensin, and Phakinin in the Development of Cataracts. Poster presented at 6th Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; November 1, 2014
2014 | Whitman JK [resident], Fleschner CR, Stuart MK. Isolation of a Ganglioside Unique to the Water-Insoluble Membrane Fraction of Rat Lens. Poster presented at the 3rd Annual Missouri Osteopathic Student and Post-graduate Research Symposium; Missouri Osteopathic Annual Convention; Branson, MO; April 30-May 4, 2014
2010 | Whitman JK [student], Fleschner CR, Stuart MK; Isolation of a Ganglioside Unique to the Water-Insoluble Fraction of Ocular Lens; Association for Research in Vision and Ophthalmology Annual Meeting; Fort Lauderdale, FL; May 2-6, 2010
2007 | Alviar AF, Fleschner CR, Stuart MK; Fragmented Forms of Galectin Related Inter-fiber Protein are Uniquely Associated with the Water Insoluble Membrane Fraction of Normal Rat Lens; 47th Annual Meeting of the American Society for Cell Biology; Washington, D.C.; Dec. 1-5, 2007
2003 | Fleschner CR. Rat Lens Membrane Fractional Distribution of Insoluble Calpain Lp82/85. 2003 Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology. Abstract 1237. Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft. Lauderdale, FL; May 5, 2003
2002 | Fleschner CR. Rat Lens Membrane Distribution of Spectrin and Ankyrin. Invest. Ophthalmol. Vis. Sci. 43: E-Abstract 459. Available at www.iovs.org. Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft. Lauderdale, FL; May 5, 2002
2001 | Fleschner CR. 2001. Intermediate Filament Peptides Associated with Cortical and Nuclear Membrane Fractions Isolated for Selenite Cataractous Lenses; Assn for Research in Vision and Ophthalmology. Invest Ophthalmol Vis Sci 42(4):S874, #4693. Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft. Lauderdale, FL; April 30, 2001
2000 | Fleschner CR. 2000. Connexins 46 and 50 are Unequally Distributed Among Membrane Fractions Isolated From Rat Lens. Invest Ophthal & Vis Sci 41:S864. Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft. Lauderdale, FL; May 4, 2000
2000 | Fleschner CR. 2000. Intermediate Filament Peptides Associated with Membrane Fractions Isolated from Selenite Cataractous Rat Lenses. Exp Eye Res Sci 71:S44. The 15th International Congress of Eye Research; Santa Fe, NM; October 16, 2000
1998 | Fleschner CR. 1998. Intermediate Filament Proteins of Membrane Fractions Isolated from Neonatal Rat Lenses. Invest Ophthalmol Vis Sci 39(Suppl):S789
1997 | Fleschner CR. 1997. Lens Epithelial Cell Differentiation in vitro. JAOA 97:541
1997 | Fleschner CR. 1997. The Bovine Lens Non-sedimenting Membrane Fraction is Eenriched with Vimentin. Association for Research in Vision Ophthalmology38(Suppl):ptII, s1034.
2014 | Foreman M [student], Fleschner C. The Role of Vimentin, Filensin, and Phakinin in the Development of Cataracts. Poster presented at 6th Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; November 1, 2014
2014 | Whitman JK [resident], Fleschner CR, Stuart MK. Isolation of a Ganglioside Unique to the Water-Insoluble Membrane Fraction of Rat Lens. Poster presented at the 3rd Annual Missouri Osteopathic Student and Post-graduate Research Symposium; Missouri Osteopathic Annual Convention; Branson, MO; April 30-May 4, 2014
2010 | Whitman JK [student], Fleschner CR, Stuart MK; Isolation of a Ganglioside Unique to the Water-Insoluble Fraction of Ocular Lens; Association for Research in Vision and Ophthalmology Annual Meeting; Fort Lauderdale, FL; May 2-6, 2010
2007 | Alviar AF, Fleschner CR, Stuart MK; Fragmented Forms of Galectin Related Inter-fiber Protein are Uniquely Associated with the Water Insoluble Membrane Fraction of Normal Rat Lens; 47th Annual Meeting of the American Society for Cell Biology; Washington, D.C.; Dec. 1-5, 2007
2003 | Fleschner CR. Rat Lens Membrane Fractional Distribution of Insoluble Calpain Lp82/85. 2003 Annual Meeting Abstract and Program Planner accessed at www.arvo.org. Association for Research in Vision and Ophthalmology. Abstract 1237. Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft. Lauderdale, FL; May 5, 2003
2002 | Fleschner CR. Rat Lens Membrane Distribution of Spectrin and Ankyrin. Invest. Ophthalmol. Vis. Sci. 43: E-Abstract 459. Available at www.iovs.org. Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft. Lauderdale, FL; May 5, 2002
2001 | Fleschner CR. 2001. Intermediate Filament Peptides Associated with Cortical and Nuclear Membrane Fractions Isolated for Selenite Cataractous Lenses; Assn for Research in Vision and Ophthalmology. Invest Ophthalmol Vis Sci 42(4):S874, #4693. Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft. Lauderdale, FL; April 30, 2001
2000 | Fleschner CR. 2000. Connexins 46 and 50 are Unequally Distributed Among Membrane Fractions Isolated From Rat Lens. Invest Ophthal & Vis Sci 41:S864. Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft. Lauderdale, FL; May 4, 2000
2000 | Fleschner CR. 2000. Intermediate Filament Peptides Associated with Membrane Fractions Isolated from Selenite Cataractous Rat Lenses. Exp Eye Res Sci 71:S44. The 15th International Congress of Eye Research; Santa Fe, NM; October 16, 2000
1998 | Fleschner CR. 1998. Intermediate Filament Proteins of Membrane Fractions Isolated from Neonatal Rat Lenses. Invest Ophthalmol Vis Sci 39(Suppl):S789
1997 | Fleschner CR. 1997. Lens Epithelial Cell Differentiation in vitro. JAOA 97:541
1997 | Fleschner CR. 1997. The Bovine Lens Non-sedimenting Membrane Fraction is Eenriched with Vimentin. Association for Research in Vision Ophthalmology38(Suppl):ptII, s1034.
