Robert J. Theobald Jr., PhD



Work: 660.626.2320
Fax: 660.626.2728
Email Address: rtheobald@atsu.edu

Research Interests: Dr. Theobald is interested in the regulation and interaction of the urinary tract. Although it is known that the urinary tract collects then eliminates urine, this seemingly simply task requires the complex integration of neural and muscular components at multiple levels. The research is designed to study the neurotransmitters, autonomic and purinergic, in the neural pathways involved in urinary tract interaction. Information provided by these studies should lead to a better understanding of the complete urinary tract and dysfunctions, such as interstitial cystitis. The studies also focus on the role of purines and other putative neurotransmitters in the lower urinary tract.

Education:

PhD - University of Pittsburgh (1975)

Scholarly Activity

Research Publications:

2003 | Theobald RJ Jr. Differing effects of NG-monomethyl L-arginine and 7-nitroindazole on detrusor activity. Neurourol Urodyn 2003;22(1):62-9

1996 | Theobald RJ Jr. The effect of NG-monomethyl-L-arginine on bladder function. Eur J Pharmacol 1996 Sep 5;311(1):73-8

1996 | Theobald RJ. Pharmacological studies to examine the source of ATP released by pelvic nerve stimulation in the feline lower urinary tract. J Auton Pharmacol 1996 Apr;16(2):111-5

1995 | Theobald RJ Jr. Purinergic and cholinergic components of bladder contractility and flow. Life Sci 1995;56(6):445-54

1993 | Bonney WW, Robinson RA, Theobald RJ Jr. Topical effect of intravesical oxybutynin. J Urol 1993 Nov;150(5 Pt 1):1522-5

1992 | Theobald RJ Jr. Subclasses of purinoceptors in feline bladder. Eur J Pharmacol 1992 Dec 15;229(2-3):125-30

1989 | Theobald RJ Jr, de Groat WD. The effects of purine nucleotides on transmission in vesical parasympathetic ganglia of the cat. J Auton Pharmacol 1989 Jun;9(3):167-81

1988 | Theobald RJ Jr, Zepp EA, Westhoff R. Endocrine influences on the detrusor of male and female cats. Neurourology and Urodynamics 1988; 7: 493-500

1986 | Theobald RJ Jr, Hoffman V. Long-lasting blockade of P2-receptors of the urinary bladder in vivo following photolysis of arylazido aminopropionyl ATP, a photoaffinity label. Life Sci 1986 Apr 28;38(17):1591-5

1986 | Theobald RJ Jr. The effect of arylazido aminopropionyl ATP (ANAPP3) on inhibition of pelvic nerve evoked contractions of the cat urinary bladder. Eur J Pharmacol 1986 Jan 29;120(3):351-4

1983 | Theobald RJ Jr. Evidence against purinergic nerve fibres in the hypogastric nerves of the cat. J Auton Pharmacol 1983 Dec;3(4):235-9

1983 | Theobald RJ Jr. The effect of arylazido aminopropionyl ATP on atropine resistant contractions of the cat urinary bladder. Life Sci 1983 May 23;32(21):2479-84

1986 | Theobald RJ Jr. Changes inureteral peristaltic activity by various stimuli. Neurourology and Urodynamics 1986; 5(5): 493-504

1982 | Theobald RJ Jr. Arylazido aminopropionyl atp (ANAPP3) antagonism of cat urinary bladder contractions. J Auton Pharmacol 1982 Sep;2(3):175-9

1976 | de Groat WC, Theobald RJ. Reflex activation of sympathetic pathways to vesical smooth muscle and parasympathetic ganglia by electrical stimulation of vesical afferents. J Physiol 1976 Jul;259(1):223-37

1973 | Buckley JP, Theobald RJ Jr, Cavero I, Krukoff BA, Leighton AP, Kupchan SM. Preliminary pharmacological evaluation of extracts of takini: Helicostylis tomentosa and Helicostylis pedunculata. Lloydia 1973 Sep;36(3):341-5

Books, Chapters, and Reviews:

2016 | Theobald RJ. Podophyllotoxin, Reference Module in Biomedical Sciences. 2016. Elsevier. 08-Jun-2016 doi:10.1016/B978-0-12-801238-3.92844-7

2016 | Theobald RJ. Clofazimine, Reference Module in Biomedical Sciences. 2016. Elsevier. 08-Jun-2016 doi:10.1016/B978-0-12-801238-3.92846-0

2016 | Theobald RJ. Sulfapyridine, Reference Module in Biomedical Sciences. 2016. Elsevier. 08-Jun-2016 doi:10.1016/B978-0-12-801238-3.92845-9

2016 | Theobald RJ. Thalidomide, Reference Module in Biomedical Sciences. 2016. Elsevier. 08-Jun-2016 doi:10.1016/B978-0-12-801238-3.92850-2

2016 | Theobald RJ. Vidarabine, Reference Module in Biomedical Sciences. 2016. Elsevier. 08-Jun-2016 doi:10.1016/B978-0-12-801238-3.92840-X

2016 | Theobald RJ. Oxyphenbutazone, Reference Module in Biomedical Sciences. 2016. Elsevier. 08-Jun-2016 doi:10.1016/B978-0-12-801238-3.92843-5

2016 | Theobald R.J. ,Azathioprine, Reference Module in Biomedical Sciences. 2016. Elsevier. 08-Jun-2016 doi:10.1016/B978-0-12-801238-3.92847-2

2016 | Theobald RJ. Coagulation Factor IXa as an Agent, Reference Module in Biomedical Sciences. 2016. Elsevier. 08-Jun-2016 doi:10.1016/B978-0-12-801238-3.92849-6

2002 | Theobald RJ Jr. 2002. Pharmacologic and osteopathic basic principles, Chapter 12, p. 189-95. In RC Ward (ed.), Foundations for Osteopathic Medicine, 2nd Edition; Lippincott, Williams and Wilkins

1997 | Theobald RJ Jr. 1997. Pharmacologic and osteopathic basic principles, Chapter 7, p. 93-97. In RC Ward (ed.), Foundations for Osteopathic Medicine, Williams and Wilkins

Presentations and Published Abstracts:

2019 | Theobald RJ Jr., B. Henry Han. Cognitiion Assessment in APP/PS1 Transgenic Mice. Presented at Federation Proceedings, Orlando, FL; April 8, 2019.

2016 | Blanchard AN, Morgan CH, Theobald, Jr. RJ. Anti-Muscarinic Drug Effects on Murine Cognition. Poster presented at the 8th Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; November 5, 2016.

2016 | Hassan SMS, Thomann C [staff], Bhatia S [staff], Theobald R. A Comparison of Three Neuroscience Curriculum Models in an Osteopathic Medical School. Poster presented at Experimental Biology meeting, San Diego, CA; April 2-6, 2016

2016 | Theobald RJ, Reuben J, Peffley D. Developing A Discipline-Based Problem Solving Set for One Medical Science to Broader Applications. Presented at: 20th Annual International Association of Medical Science Educators Meeting; Leiden, The Netherlands; June 4-7, 2016.

2009 | Gaffney J [student], Theobald RJ, Chang Y; Calcium flux in urinary bladder smooth muscle cells; Presented at the 1st Annual Interdisciplinary Biomedical Research Symposium; A.T. Still University of Health Sciences; Kirksville, MO; Sept. 26, 2009.

2009 | Ignash S [student], Theobald Jr. R; Urodynamic Responses of Juvenile and Adult Cats to Nitric Oxide Donor Administration; Experimental Biology 2009: Translational Medical Research Symposia; New Orleans, LA; April 18 - 22, 2009.

2004 | Theobald RJ, Geisbuhler TP; CB1 Receptor Antagonist SR141716A Effects in Detrusor Smooth Muscle; FASEB J 18: A598; 2004.

2001 | Theobald RJ Jr. 2001. Cannabinoid Induced Changes in Detrusor Activity. FASEB Journal 15(4, Part 1):A582.

2000 | Theobald Jr., RJ. Effects of CP55,940 and Methanadamide on Detrusor Activity; NIH Interstitial Cystitis & Bladder Research Symposium; Minneapolis, MN; Oct. 18, 2000.

1999 | Theobald RJ Jr. 1999. Evidence for a Role of Urothelial Derived NO in Detrusor Relaxation. Experimental Biology 99.

1999 | Theobald RJ Jr. Detrusor Regulation by Purine and Nitrergic Agents; Merck Research Labs (West Point, PA); Oct. 28, 1999.

1998 | Theobald RJ Jr. 1998. Verapamil Effects on Detrusor Contraction Kinetics. FASEB J. 12:A141.

1997 | Theobald RJ Jr. 1997. Proposed Purinergic-nitrergic Interactions in the Feline Urinary Bladder. American Urological Association (New Orleans, LA).