Daniela Ostrowski, PhD
Assistant Professor
Work: 660.626.2323
Fax: 660.626.2728
Fax: 660.626.2728
Email Address: Danielaostrowski@atsu.edu
Research Interests:
1. Understand the cellular mechanisms behind Alzheimer’s disease (AD) using a non-transgenic rodent animal model to mimic the sporadic form of AD with focus on cardiorespiratory issues related to AD.
2. Study the cellular and molecular mechanisms by which the cytokine erythropoietin (Epo) protects respiratory motor neurons from injury using a rodent model for amyotrophic lateral sclerosis (ALS).
Education:
Post-doctoral Fellow - (Biomedical Sciences) University of Missouri-Columbia (2012-2014)Post-doctoral Fellow - (Biology) University of Missouri-Columbia (2010-2012)
PhD - (Neurobiology): Georg-August-University of Göttingen (2009)
Scholarly Activity
Research Publications:
2023 |
Ostrowski D, Heesch CM, Kline DD, Hasser EM (2023) Nucleus tractus solitarii is required for the initiation and maintenance of phrenic and sympathetic long-term facilitation after acute intermittent hypoxia. Front. Physiol. 14:1120341.
2022 | Ehlen JC, Forman, CM, Ostrowski D, Ostrowski TD (2022) Autonomic Dysfunction Impairs Baroreflex Function in an Alzheimer’s Disease Animal Model.” J Alzheimers Dis. 2022; 90(4): 1449–1464. doi: 10.3233/JAD-220496
2022 | Humphrey CM, Hooker JW 4th, Thapa M, Wilcox MJ, Ostrowski D, Ostrowski TD. (2022) Synaptic loss and gliosis in the nucleus tractus solitarii with streptozotocin-induced Alzheimer's disease. Brain Res. 2022 Dec 12;1801:148202. doi: 10.1016/j.brainres.2022.148202 Epub ahead of print. PMID: 36521513.
2018 | Ostrowski D, Salari A, Zars M, Zars T (2018) A biphasic locomotor response to acute unsignaled high temperature exposure in Drosophila. PLoS ONE 13(6): e0198702.
2017 | Sitaraman D, Kramer EF, Kahsai L, Ostrowski D, Zars T (2017) Discrete serotonin systems mediate memory enhancement and escape latencies after unpredicted aversive experience in Drosophila place memory. Frontiers in Systems Neuroscience 11:92.
2015 | Ostrowski D, Kahsai L, Kramer EF, Knutson P, Zars T (2015) Place memory retention in Drosophila. Neurobiology of Learning and Memory 123:217-24
2014 | Ostrowski TD, Ostrowski D, Hasser EM, Kline DD (2014) Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function. Journal of Neurophysiology 111(12):2493-504
2014 | Miljus N, Heibeck S, Jarrar M, Micke M, Ostrowski D, Ehrenreich H, Heinrich R (2014) Erythropoietin-mediated protection of insect brain neurons involves JAK and STAT but not PI3K transduction pathways. Neuroscience 258:218-27
2011 | Ostrowski D, Ehrenreich H, Heinrich R (2011) Erythropoietin promotes survival and regeneration of insect neurons in vivo and in vitro. Neuroscience 188:95-108
2011 | Laferriere H, Ostrowski D, Guarnieri DJ, Zars T (2011) The arouser EPS8L3 gene is critical for normal memory in Drosophila. PLoS ONE 6, e22867
2009 | Gocht D#, Wagner S, Heinrich R (2009) Recognition, presence and survival of locust central nervous glia in situ and in vitro. Microscopy and Research Technique 72(5): 385-397
2008 | 12. Kube D, Hua T-D, Bonin F, Schoof N, Zeynalova S, Klöss M, Gocht D#, Potthoff B, Tzvetkov M, Brockmöller J, Löffler M, Pfreundschuh M, Trümper L (2008) Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study. Clinical Cancer Research 14(12): 3777-3784
2007 | Hoffmann K, Wirmer A, Kunst M, Gocht D#, Heinrich R (2007) Muscarinic excitation in grasshopper song control circuits is limited by acetylcholinesterase activity. Zoological Science 24: 1028-1035
2006 | Gocht D#, Heinrich R (2006) Postactivation inhibition of spontaneously active neurosecretory neurons in the medicinal leech. Journal of Comparative Physiology A 193: 347–361
2022 | Ehlen JC, Forman, CM, Ostrowski D, Ostrowski TD (2022) Autonomic Dysfunction Impairs Baroreflex Function in an Alzheimer’s Disease Animal Model.” J Alzheimers Dis. 2022; 90(4): 1449–1464. doi: 10.3233/JAD-220496
2022 | Humphrey CM, Hooker JW 4th, Thapa M, Wilcox MJ, Ostrowski D, Ostrowski TD. (2022) Synaptic loss and gliosis in the nucleus tractus solitarii with streptozotocin-induced Alzheimer's disease. Brain Res. 2022 Dec 12;1801:148202. doi: 10.1016/j.brainres.2022.148202 Epub ahead of print. PMID: 36521513.
2018 | Ostrowski D, Salari A, Zars M, Zars T (2018) A biphasic locomotor response to acute unsignaled high temperature exposure in Drosophila. PLoS ONE 13(6): e0198702.
2017 | Sitaraman D, Kramer EF, Kahsai L, Ostrowski D, Zars T (2017) Discrete serotonin systems mediate memory enhancement and escape latencies after unpredicted aversive experience in Drosophila place memory. Frontiers in Systems Neuroscience 11:92.
2015 | Ostrowski D, Kahsai L, Kramer EF, Knutson P, Zars T (2015) Place memory retention in Drosophila. Neurobiology of Learning and Memory 123:217-24
2014 | Ostrowski TD, Ostrowski D, Hasser EM, Kline DD (2014) Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function. Journal of Neurophysiology 111(12):2493-504
2014 | Miljus N, Heibeck S, Jarrar M, Micke M, Ostrowski D, Ehrenreich H, Heinrich R (2014) Erythropoietin-mediated protection of insect brain neurons involves JAK and STAT but not PI3K transduction pathways. Neuroscience 258:218-27
2011 | Ostrowski D, Ehrenreich H, Heinrich R (2011) Erythropoietin promotes survival and regeneration of insect neurons in vivo and in vitro. Neuroscience 188:95-108
2011 | Laferriere H, Ostrowski D, Guarnieri DJ, Zars T (2011) The arouser EPS8L3 gene is critical for normal memory in Drosophila. PLoS ONE 6, e22867
2009 | Gocht D#, Wagner S, Heinrich R (2009) Recognition, presence and survival of locust central nervous glia in situ and in vitro. Microscopy and Research Technique 72(5): 385-397
2008 | 12. Kube D, Hua T-D, Bonin F, Schoof N, Zeynalova S, Klöss M, Gocht D#, Potthoff B, Tzvetkov M, Brockmöller J, Löffler M, Pfreundschuh M, Trümper L (2008) Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study. Clinical Cancer Research 14(12): 3777-3784
2007 | Hoffmann K, Wirmer A, Kunst M, Gocht D#, Heinrich R (2007) Muscarinic excitation in grasshopper song control circuits is limited by acetylcholinesterase activity. Zoological Science 24: 1028-1035
2006 | Gocht D#, Heinrich R (2006) Postactivation inhibition of spontaneously active neurosecretory neurons in the medicinal leech. Journal of Comparative Physiology A 193: 347–361
Books, Chapters, and Reviews:
2018 |
Ostrowski D, Heinrich R (2018) Alternative Erythropoietin Receptors in the Nervous System. Journal of Clinical Medicine. 2018; 7(2):24.
2013 | Ostrowski D, Zars T (2013) Place memory. In: Handbook of Behavior Genetics of Drosophila melanogaster: Behavioral Phenotypes and Models of Neurobehavioral Disorders. J. Dubnau, ed. Cambridge, UK. Cambridge University Press. 125-135 ISBN: 9781139950084
2011 | Ostrowski D, Zars T (2011) Genetics of memory. In: Yearbook of Science and Technology. R. Kasunic, ed. McGraw-Hill, New York. 121-124
2013 | Ostrowski D, Zars T (2013) Place memory. In: Handbook of Behavior Genetics of Drosophila melanogaster: Behavioral Phenotypes and Models of Neurobehavioral Disorders. J. Dubnau, ed. Cambridge, UK. Cambridge University Press. 125-135 ISBN: 9781139950084
2011 | Ostrowski D, Zars T (2011) Genetics of memory. In: Yearbook of Science and Technology. R. Kasunic, ed. McGraw-Hill, New York. 121-124
Presentations and Published Abstracts:
2020 |
Humphrey CH, Hooker JW, Thapa M, Wilcox, MJ, Ostrowski D, Ostrowski TD (2020) Effect of Streptozotocin (STZ) Concentration on Chemoreflex Function and Morphology of the Nucleus Tractus Solitarii in STZ‐Induced Alzheimer’s Disease. Experimental Biology Conference, San Diego, CA, USA, FASEB J 558.5
2019 | Ostrowski D (2019) “Alternative Erythropoietin Receptors in the Nervous System” 13th Göttingen Meeting of the German Neuroscience Society in Göttingen, Germany https://www.nwg-goettingen.de/2019/upload/file/symposia/S3_Hahn_Heinrich.pdf
2019 | Ehlen JC, Ostrowski D, Ostrowski TD (2019) Reduced Baroreflex Function in the STZ-Induced Rat Model of Alzheimer’s Disease. Experimental Biology Conference, Orlando, FL, USA, FASEB J 558.5
2015 | Ostrowski D, Heesch CM, Kline DD, Hasser EM (2015) nTS ROS contribute to acute intermittent hypoxia-induced phrenic and sympathetic LTF. 9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in conjunction with Federation of European Autonomic Societies (EFAS), American Autonomic Society (AAS), Japan Society of Neurovegetative Research (JSNR), Stresa, Italy
2014 | Ostrowski TD, Kline DD, Hasser EM & Ostrowski D (2014) The role of nucleus tractus solitarii (nTS) neurons in cardiorespiratory dysfunction associated with Alzheimer’s disease. Experimental Biology, Boston, MA, USA, FASEB J 985.6
2014 | Ostrowski D, Ruyle B, Kleiber A, Kline DD, Heesch CM, Hasser EM (2014) Nucleus tractus solitarii reactive oxygen species contribute to acute intermittent hypoxia-induced long-term facilitation of phrenic and splanchnic sympathetic nerve activity. Experimental Biology Conference, Boston, MA, USA, FASEB J 686.26
2013 | Ostrowski D, Kleiber AC, Heesch CM, Kline DD, Hasser EM (2013) Nucleus tractus solitarii (nTS) is required for phrenic long term facilitation (pLTF) after acute intermittent hypoxia (AIH). Experimental Biology Conference, Boston, MA, USA, FASEB J 686.26
2013 | Kleiber AC, Ostrowski D, Heesch CM, Kline DD, Hasser EM (2013) Nucleus tractus solitarii (nTS) reactive oxygen species (ROS) contribute to acute intermittent hypoxia (AIH)-induced phrenic nerve long-term facilitation (pLTF). Experimental Biology Conference, Boston, MA, USA, FASEB J 697.27
2012 | Miljus N, Ostrowski D, Ehrenreich H, Heinrich R (2012) Erythropoietin promotes survival and regeneration of insect neurons in vivo and in vitro. 9th International Lübeck Conference, Lübeck, Germany, focus 16
2011 | Ostrowski D, Zars T (2011) “Influence of high temperature experience on locomotor behavior of Drosophila.” Midwest Drosophila Conference in Iowa City, USA
2009 | Gocht D#, Wagner S, Heinrich R (2009) Recognition, presence and survival of locust central nervous glia in situ and in vitro. 32nd Göttingen Neurobiology Conference - 8th Meeting of the German Neuroscience Society in Göttingen, Germany, Proceedings T9-1A
2007 | Gocht D#, Sargin D, Sperling S, Ehrenreich H, Heinrich R (2007) Expression and function of human erythropoietin-responsive receptors in invertebrate nervous systems. 37th annual meeting of the Society for Neuroscience in San Diego, USA, OASIS 873.4/E14
2007 | Gocht D#, Sargin D, Sperling S, Ehrenreich H, Heinrich R (2007) Expression and function of erythropoietin and its receptor in invertebrate nervous systems. 31st Göttingen Neurobiology Conference - 7th Meeting of the German Neuroscience Society in Göttingen, Germany, Proceedings T3-6A
2005 | Kube D, Hua T-D, Kulle B, Gocht D#, Kloess M, Brockmöller J, Wojnowski L, Löffler M, Pfreundschuh M, Trümper L (2005) Interleukin-10 gene promoter polymorphisms in aggressive Non-Hodgkin lymphoma. 9th International Conference on Malignant Lymphoma in Lugano, Switzerland, ICML 134
2005 | Gocht D#, Heinrich R (2005) Postactivation inhibition of spontaneously active serotonin-releasing neurosecretory cells in the medicinal leech. 30st Göttingen Neurobiology Conference - 6th Meeting of the German Neuroscience Society in Göttingen, Germany, Proceedings 301-A
2019 | Ostrowski D (2019) “Alternative Erythropoietin Receptors in the Nervous System” 13th Göttingen Meeting of the German Neuroscience Society in Göttingen, Germany https://www.nwg-goettingen.de/2019/upload/file/symposia/S3_Hahn_Heinrich.pdf
2019 | Ehlen JC, Ostrowski D, Ostrowski TD (2019) Reduced Baroreflex Function in the STZ-Induced Rat Model of Alzheimer’s Disease. Experimental Biology Conference, Orlando, FL, USA, FASEB J 558.5
2015 | Ostrowski D, Heesch CM, Kline DD, Hasser EM (2015) nTS ROS contribute to acute intermittent hypoxia-induced phrenic and sympathetic LTF. 9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in conjunction with Federation of European Autonomic Societies (EFAS), American Autonomic Society (AAS), Japan Society of Neurovegetative Research (JSNR), Stresa, Italy
2014 | Ostrowski TD, Kline DD, Hasser EM & Ostrowski D (2014) The role of nucleus tractus solitarii (nTS) neurons in cardiorespiratory dysfunction associated with Alzheimer’s disease. Experimental Biology, Boston, MA, USA, FASEB J 985.6
2014 | Ostrowski D, Ruyle B, Kleiber A, Kline DD, Heesch CM, Hasser EM (2014) Nucleus tractus solitarii reactive oxygen species contribute to acute intermittent hypoxia-induced long-term facilitation of phrenic and splanchnic sympathetic nerve activity. Experimental Biology Conference, Boston, MA, USA, FASEB J 686.26
2013 | Ostrowski D, Kleiber AC, Heesch CM, Kline DD, Hasser EM (2013) Nucleus tractus solitarii (nTS) is required for phrenic long term facilitation (pLTF) after acute intermittent hypoxia (AIH). Experimental Biology Conference, Boston, MA, USA, FASEB J 686.26
2013 | Kleiber AC, Ostrowski D, Heesch CM, Kline DD, Hasser EM (2013) Nucleus tractus solitarii (nTS) reactive oxygen species (ROS) contribute to acute intermittent hypoxia (AIH)-induced phrenic nerve long-term facilitation (pLTF). Experimental Biology Conference, Boston, MA, USA, FASEB J 697.27
2012 | Miljus N, Ostrowski D, Ehrenreich H, Heinrich R (2012) Erythropoietin promotes survival and regeneration of insect neurons in vivo and in vitro. 9th International Lübeck Conference, Lübeck, Germany, focus 16
2011 | Ostrowski D, Zars T (2011) “Influence of high temperature experience on locomotor behavior of Drosophila.” Midwest Drosophila Conference in Iowa City, USA
2009 | Gocht D#, Wagner S, Heinrich R (2009) Recognition, presence and survival of locust central nervous glia in situ and in vitro. 32nd Göttingen Neurobiology Conference - 8th Meeting of the German Neuroscience Society in Göttingen, Germany, Proceedings T9-1A
2007 | Gocht D#, Sargin D, Sperling S, Ehrenreich H, Heinrich R (2007) Expression and function of human erythropoietin-responsive receptors in invertebrate nervous systems. 37th annual meeting of the Society for Neuroscience in San Diego, USA, OASIS 873.4/E14
2007 | Gocht D#, Sargin D, Sperling S, Ehrenreich H, Heinrich R (2007) Expression and function of erythropoietin and its receptor in invertebrate nervous systems. 31st Göttingen Neurobiology Conference - 7th Meeting of the German Neuroscience Society in Göttingen, Germany, Proceedings T3-6A
2005 | Kube D, Hua T-D, Kulle B, Gocht D#, Kloess M, Brockmöller J, Wojnowski L, Löffler M, Pfreundschuh M, Trümper L (2005) Interleukin-10 gene promoter polymorphisms in aggressive Non-Hodgkin lymphoma. 9th International Conference on Malignant Lymphoma in Lugano, Switzerland, ICML 134
2005 | Gocht D#, Heinrich R (2005) Postactivation inhibition of spontaneously active serotonin-releasing neurosecretory cells in the medicinal leech. 30st Göttingen Neurobiology Conference - 6th Meeting of the German Neuroscience Society in Göttingen, Germany, Proceedings 301-A
