Suhail Akhtar, PhD
Assistant Professor
Work: (660) 626.2624
Fax: (660) 626.2981
Fax: (660) 626.2981
Email Address: suhailakhtar@atsu.edu
Research Interests: The human gut microbiota consists of trillions of bacteria. These bacteria are key to many aspects of human health including immune function. Several factors e.g., alcohol, major trauma and certain diseased conditions alter the composition of gut microbiota and can also affect the immune system. These changes may be associated with gut inflammation and disruption of intestinal epithelial barrier. This can lead to translocation of bacteria and/or their products from the intestinal lumen into the circulation resulting in systemic inflammation and tissue damage. The focus of my research is to identify the molecular mechanisms of gut barrier dysfunction following major trauma, alcohol exposure, and under certain diseased conditions. I am also interested in determining the relationship between imbalance in gut microbial composition (dysbiosis), gut mucosal immunity and epithelial barrier function.
Education:
Research Associate - Northwestern University, Chicago, IL (2019)PhD - Biochemistry, Aligarh University, Aligarh, India (2005)
MS - Biotechnology, Aligarh University, Aligarh, India (2000)
BS - Biochemistry, Aligarh University, Aligarh, India (1997)
Scholarly Activity
Research Publications:
2021 |
Thomas A, Sumughan S, Dellacecca ER, Shivde RS, Lancki N, Mukhatayev Z, Vaca C, Han F, Barse L, Hammer AM, Henning S, Zamora-Pineda J, Akhtar S, Gupta N, Zahid JO, Zack S, Lo A, Moss J, Picken MM, Darling TN, Scholtens DM, Dilling DF, Junghans RP, Le Poole IC. Loss of TSC2 renders benign mouse tumors sensitive to GD3 CAR T-cells. Manuscript submitted to PNAS.
2020 | Dellacecca ER, Cosgrove C, Mukhatayev Z, Akhtar S, Engelhard VH, Rademaker AW, Knight K, Le Poole IC. Antibiotics drive microbial imbalance and vitiligo development in mice. J Invest Dermatol. pii: S0022-202X(19)33153-7. doi: 10.1016/j.jid.2019.08.435. PMID: 31472106. PubMed
2019 | Younge N, McCann JR, Ballard J, Plunkett C, Akhtar S, Araújo-Pérez F, Murtha A, Brandon D, Seed PC. Fetal exposure to the maternal microbiota in humans and mice. JCI Insight. 2019 Sep 3. pii: 127806. doi: 10.1172/jci.insight.127806. PMID:31479427. PubMed
2019 | Siddiqui MR, Akhtar S, Shahid M, Tauseef M, McDonough K, Shanley TP. miR-144-mediated Inhibition of ROCK1 Protects against LPS-induced Lung Endothelial Hyperpermeability. Am J Respir Cell Mol Biol. 2019 Aug;61(2):257-265. doi: 10.1165/rcmb.2018-0235OC. PMID: 30811958. PubMed
2016 | Cannon AR, Akhtar S, Hammer AM, Morris NL, Javorski MJ, Li X, Kennedy RH, Gamelli RL, Choudhry MA. Effects of Mesalamine Treatment on Gut Barrier Integrity After Burn Injury. J Burn Care Res. 2016 Sep-Oct;37(5):283-92. doi: 10.1097/BCR.0000000000000396. PMID: 27388883. PubMed
2016 | Wang P, Du C, Chen FX, Li CQ, Yu YB, Han T, Akhtar S, Zuo XL, Tan XD, Li YQ. BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit. Sci Rep. 2016 Feb 3;6:20320. doi: 10.1038/srep20320. PMID:26837784. PubMed
2015 | Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, Hammer AM, Morris NL, Li X, Eberhardt JM, Gamelli RL, Kennedy RH, Choudhry MA. Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation. PLoS One. 2015 Jul 8;10(7):e0129996. doi: 10.1371/journal.pone.0129996. eCollection 2015. PMID: 26154283. PubMed
2015 | Jabir NR, Firoz CK, Baeesa SS, Ashraf GM, Akhtar S, Kamal W, Kamal MA, Tabrez S. Synopsis on the linkage of Alzheimer's and Parkinson's disease with chronic diseases. CNS Neurosci Ther. 2015 Jan;21(1):1-7. doi: 10.1111/cns.12344. Epub 2014 Nov 15. PMID: 25399848. PubMed
2013 | Khan MA, Moeez S, Akhtar S. T-regulatory cell-mediated immune tolerance as a potential immunotherapeutic strategy to facilitate graft survival. Blood Transfus. 2013 Jul;11(3):357-63. doi: 10.2450/2013.0258-12. PMID: 23736920. PubMed
2013 | Sigman M, Conrad P, Rendon JL, Akhtar S, Eberhardt J, Gamelli RL, Choudhry MA. Noninvasive measurement of intestinal inflammation after burn injury. J Burn Care Res. 2013 Nov-Dec;34(6):633-8. doi: 10.1097/BCR.0b013e318280e2f8. PMID: 23511286. PubMed
2013 | Rendon JL, Li X, Akhtar S, Choudhry MA. Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury. Shock. 2013 Jan;39(1):11-8. doi: 10.1097/SHK.0b013e3182749f96. PMID: 23143063. PubMed
2012 | Li X, Rendon JL, Akhtar S, Choudhry MA. Activation of toll-like receptor 2 prevents suppression of T-cell interferon γ production by modulating p38/extracellular signal-regulated kinase pathways following alcohol and burn injury. Mol Med. 2012 Sep 7;18:982-91. doi: 10.2119/molmed.2011.00513. PMID: 22634720. PubMed
2012 | Li X, Akhtar S, Choudhry MA. Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Biochim Biophys Acta. 2012 Feb;1822(2):196-203. doi: 10.1016/j.bbadis.2011.09.019. Epub 2011 Oct 7. PMID: 22001439. PubMed
2011 | Akhtar S, Choudhry MA. Gut inflammation in response to injury: potential target for therapeutic intervention. Recent Pat Antiinfect Drug Discov. 2011 Sep 1;6(3):206-15. PMID: 21824071. PubMed
2011 | Li X, Akhtar S, Kovacs EJ, Gamelli RL, Choudhry MA. Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury. J Burn Care Res. 2011 Jul-Aug;32(4):489-97. doi: 10.1097/BCR.0b013e3182223c9e. PMID: 21593683. PubMed
2011 | Akhtar S, Li X, Kovacs EJ, Gamelli RL, Choudhry MA. Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury. Mol Med. 2011 Jan-Feb;17(1-2):88-94. doi: 10.2119/molmed.2010.00080. PMID: 20844839. PubMed
2009 | Akhtar S, Li X, Chaudry IH, Choudhry MA. Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G340-7. doi: 10.1152/ajpgi.00044.2009. PMID: 19497959. PubMed
2009 | Akhtar S, Meeran SM, Katiyar N, Katiyar SK. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation and angiogenic factors. Clin Cancer Res, 15(3): 821-31, 2009.
2009 | Meeran SM, Akhtar S, Katiyar SK. Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation. J Invest Dermatol, 129(5): 1258-70, 2009.
2009 | Katiyar SK, Meeran SM, Katiyar N, Akhtar S. p53 cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol Carcinog, 48: 24-37, 2009.
2006 | Akhtar S, Husain Q. Potential applications of immobilized bitter gourd (Momordica charantia) peroxidase in the removal of phenols from polluted water. Chemosphere, 65: 1228-35, 2006.
2006 | Khan AA, Akhtar S, Husain Q. Direct immobilization of polyphenol oxidases on Celite-545 from ammonium sulphate fractionated proteins of potato (Solanum tuberosum). J Mol Catal B: Enzymatic, 40: 58-63, 2006.
2005 | Akhtar S, Khan AA, Husain Q. Simultaneous purification and immobilization of bitter gourd (Momordica charantia) peroxidases on bioaffinity support. J Chem Technol Biotech, 80: 198-205, 2005.
2005 | Akhtar S, Khan AA, Husain Q. Potential of immobilized bitter gourd (Momordica charantia) peroxidases in the decolorization and removal of textile dyes from polluted wastewater and dyeing effluent. Chemosphere, 60: 291-301, 2005.
2005 | Akhtar S, Khan AA, Husain Q. Partially purified bitter gourd (Momordica charantia) peroxidase catalyzed decolorization of textile and other industrially important dyes. Biores Technol, 96: 1804-1811, 2005.
2005 | Khan AA, Akhtar S, Husain Q. Simultaneous purification and immobilization of mushroom tyrosinase on immunoaffinity support. Process Biochem, 40: 2379-2386, 2005.
2005 | Khan AA, Akhtar S, Husain Q. Adsorption of polyphenol oxidases on Celite-545 directly from ammonium sulphate fractionated proteins of brinjal (Solanum melongena). J Sci Indust Res, 64: 621-626, 2005. http://nopr.niscair.res.in/handle/123456789/5115
2005 | Deeba F, Nasti TH, Sharma S, Ahmad N, Akhtar S, Saleemuddin M, Owais M. Phospholipid diversity: Correlation with membrane-membrane fusion events. BBABiomembranes, 1669: 170-181, 2005.
2005 | 11 Meeran SM, Akhtar S, Khan AA, Husain Q. An economical, simple and high yield procedure for the immobilization/stabilization of peroxidases from turnip roots. J Sci Indust Res, 63: 540-547, 2004. http://nopr.niscair.res.in/handle/123456789/5456
2020 | Dellacecca ER, Cosgrove C, Mukhatayev Z, Akhtar S, Engelhard VH, Rademaker AW, Knight K, Le Poole IC. Antibiotics drive microbial imbalance and vitiligo development in mice. J Invest Dermatol. pii: S0022-202X(19)33153-7. doi: 10.1016/j.jid.2019.08.435. PMID: 31472106. PubMed
2019 | Younge N, McCann JR, Ballard J, Plunkett C, Akhtar S, Araújo-Pérez F, Murtha A, Brandon D, Seed PC. Fetal exposure to the maternal microbiota in humans and mice. JCI Insight. 2019 Sep 3. pii: 127806. doi: 10.1172/jci.insight.127806. PMID:31479427. PubMed
2019 | Siddiqui MR, Akhtar S, Shahid M, Tauseef M, McDonough K, Shanley TP. miR-144-mediated Inhibition of ROCK1 Protects against LPS-induced Lung Endothelial Hyperpermeability. Am J Respir Cell Mol Biol. 2019 Aug;61(2):257-265. doi: 10.1165/rcmb.2018-0235OC. PMID: 30811958. PubMed
2016 | Cannon AR, Akhtar S, Hammer AM, Morris NL, Javorski MJ, Li X, Kennedy RH, Gamelli RL, Choudhry MA. Effects of Mesalamine Treatment on Gut Barrier Integrity After Burn Injury. J Burn Care Res. 2016 Sep-Oct;37(5):283-92. doi: 10.1097/BCR.0000000000000396. PMID: 27388883. PubMed
2016 | Wang P, Du C, Chen FX, Li CQ, Yu YB, Han T, Akhtar S, Zuo XL, Tan XD, Li YQ. BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit. Sci Rep. 2016 Feb 3;6:20320. doi: 10.1038/srep20320. PMID:26837784. PubMed
2015 | Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, Hammer AM, Morris NL, Li X, Eberhardt JM, Gamelli RL, Kennedy RH, Choudhry MA. Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation. PLoS One. 2015 Jul 8;10(7):e0129996. doi: 10.1371/journal.pone.0129996. eCollection 2015. PMID: 26154283. PubMed
2015 | Jabir NR, Firoz CK, Baeesa SS, Ashraf GM, Akhtar S, Kamal W, Kamal MA, Tabrez S. Synopsis on the linkage of Alzheimer's and Parkinson's disease with chronic diseases. CNS Neurosci Ther. 2015 Jan;21(1):1-7. doi: 10.1111/cns.12344. Epub 2014 Nov 15. PMID: 25399848. PubMed
2013 | Khan MA, Moeez S, Akhtar S. T-regulatory cell-mediated immune tolerance as a potential immunotherapeutic strategy to facilitate graft survival. Blood Transfus. 2013 Jul;11(3):357-63. doi: 10.2450/2013.0258-12. PMID: 23736920. PubMed
2013 | Sigman M, Conrad P, Rendon JL, Akhtar S, Eberhardt J, Gamelli RL, Choudhry MA. Noninvasive measurement of intestinal inflammation after burn injury. J Burn Care Res. 2013 Nov-Dec;34(6):633-8. doi: 10.1097/BCR.0b013e318280e2f8. PMID: 23511286. PubMed
2013 | Rendon JL, Li X, Akhtar S, Choudhry MA. Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury. Shock. 2013 Jan;39(1):11-8. doi: 10.1097/SHK.0b013e3182749f96. PMID: 23143063. PubMed
2012 | Li X, Rendon JL, Akhtar S, Choudhry MA. Activation of toll-like receptor 2 prevents suppression of T-cell interferon γ production by modulating p38/extracellular signal-regulated kinase pathways following alcohol and burn injury. Mol Med. 2012 Sep 7;18:982-91. doi: 10.2119/molmed.2011.00513. PMID: 22634720. PubMed
2012 | Li X, Akhtar S, Choudhry MA. Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Biochim Biophys Acta. 2012 Feb;1822(2):196-203. doi: 10.1016/j.bbadis.2011.09.019. Epub 2011 Oct 7. PMID: 22001439. PubMed
2011 | Akhtar S, Choudhry MA. Gut inflammation in response to injury: potential target for therapeutic intervention. Recent Pat Antiinfect Drug Discov. 2011 Sep 1;6(3):206-15. PMID: 21824071. PubMed
2011 | Li X, Akhtar S, Kovacs EJ, Gamelli RL, Choudhry MA. Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury. J Burn Care Res. 2011 Jul-Aug;32(4):489-97. doi: 10.1097/BCR.0b013e3182223c9e. PMID: 21593683. PubMed
2011 | Akhtar S, Li X, Kovacs EJ, Gamelli RL, Choudhry MA. Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury. Mol Med. 2011 Jan-Feb;17(1-2):88-94. doi: 10.2119/molmed.2010.00080. PMID: 20844839. PubMed
2009 | Akhtar S, Li X, Chaudry IH, Choudhry MA. Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G340-7. doi: 10.1152/ajpgi.00044.2009. PMID: 19497959. PubMed
2009 | Akhtar S, Meeran SM, Katiyar N, Katiyar SK. Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation and angiogenic factors. Clin Cancer Res, 15(3): 821-31, 2009.
2009 | Meeran SM, Akhtar S, Katiyar SK. Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through DNA repair and subsequent inhibition of inflammation. J Invest Dermatol, 129(5): 1258-70, 2009.
2009 | Katiyar SK, Meeran SM, Katiyar N, Akhtar S. p53 cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol Carcinog, 48: 24-37, 2009.
2006 | Akhtar S, Husain Q. Potential applications of immobilized bitter gourd (Momordica charantia) peroxidase in the removal of phenols from polluted water. Chemosphere, 65: 1228-35, 2006.
2006 | Khan AA, Akhtar S, Husain Q. Direct immobilization of polyphenol oxidases on Celite-545 from ammonium sulphate fractionated proteins of potato (Solanum tuberosum). J Mol Catal B: Enzymatic, 40: 58-63, 2006.
2005 | Akhtar S, Khan AA, Husain Q. Simultaneous purification and immobilization of bitter gourd (Momordica charantia) peroxidases on bioaffinity support. J Chem Technol Biotech, 80: 198-205, 2005.
2005 | Akhtar S, Khan AA, Husain Q. Potential of immobilized bitter gourd (Momordica charantia) peroxidases in the decolorization and removal of textile dyes from polluted wastewater and dyeing effluent. Chemosphere, 60: 291-301, 2005.
2005 | Akhtar S, Khan AA, Husain Q. Partially purified bitter gourd (Momordica charantia) peroxidase catalyzed decolorization of textile and other industrially important dyes. Biores Technol, 96: 1804-1811, 2005.
2005 | Khan AA, Akhtar S, Husain Q. Simultaneous purification and immobilization of mushroom tyrosinase on immunoaffinity support. Process Biochem, 40: 2379-2386, 2005.
2005 | Khan AA, Akhtar S, Husain Q. Adsorption of polyphenol oxidases on Celite-545 directly from ammonium sulphate fractionated proteins of brinjal (Solanum melongena). J Sci Indust Res, 64: 621-626, 2005. http://nopr.niscair.res.in/handle/123456789/5115
2005 | Deeba F, Nasti TH, Sharma S, Ahmad N, Akhtar S, Saleemuddin M, Owais M. Phospholipid diversity: Correlation with membrane-membrane fusion events. BBABiomembranes, 1669: 170-181, 2005.
2005 | 11 Meeran SM, Akhtar S, Khan AA, Husain Q. An economical, simple and high yield procedure for the immobilization/stabilization of peroxidases from turnip roots. J Sci Indust Res, 63: 540-547, 2004. http://nopr.niscair.res.in/handle/123456789/5456
Books, Chapters, and Reviews:
2021 |
Akhtar S, Ahmad Z. Venom peptidomimetics as therapeutics. Book chapter submitted to Current Topics in Medicinal Chemistry on Apr 30, 2021. Current status: Under revision.
2014 | Akhtar S, Wang S, Bu HF, Tan XD. Role of MFG-E8 in protection of intestinal epithelial barrier function and attenuation of intestinal inflammation. MFG-E8 and inflammation, Chapter 3. Wang, Ping (Ed), page 55-63, 2014. Publisher: Springer Netherlands.
2013 | Khan MA, Moeez S, Akhtar S. T-regulatory cell-mediated immune tolerance as a potential immunotherapeutic strategy to facilitate graft survival (Review). Blood Transfusion 11: 357-63, 2013.
2011 | Akhtar S, Choudhry MA. Gut inflammation in response to injury: Potential target for therapeutic intervention (Review). Recent Pat Anti infect Drug Discov 6: 206-215, 2011.
2014 | Akhtar S, Wang S, Bu HF, Tan XD. Role of MFG-E8 in protection of intestinal epithelial barrier function and attenuation of intestinal inflammation. MFG-E8 and inflammation, Chapter 3. Wang, Ping (Ed), page 55-63, 2014. Publisher: Springer Netherlands.
2013 | Khan MA, Moeez S, Akhtar S. T-regulatory cell-mediated immune tolerance as a potential immunotherapeutic strategy to facilitate graft survival (Review). Blood Transfusion 11: 357-63, 2013.
2011 | Akhtar S, Choudhry MA. Gut inflammation in response to injury: Potential target for therapeutic intervention (Review). Recent Pat Anti infect Drug Discov 6: 206-215, 2011.
