Yohei Norimatsu, PhD



Work: 660.626.2321
Fax: 660.626.2965
Email Address: ynorimatsu@atsu.edu

Research Interests: Dr. Norimatsu's research interests include the following: 1. Electrophysiological characterization of cystic fibrosis 2. Transmembrane Conductance Regulator (CFTR) channel with the use of chemical modification 3. Functional study of drug-receptor interactions 4. Atomic-scale molecular modeling. virtual ligand docking, molecular dynamics simulation

Education:

PhD - Flinders University of South Australia, 2005 (Areas of Study: Biophysics, Electrophysiology, Molecular Biology)
Post-doctoral Fellow - Oregon Health Sciences University (2005-2011)

Scholarly Activity

Research Publications:

2016 | Wang G, Linsley R [student], Norimatsu Y. External Zn(2+) binding to cysteine-substituted cystic fibrosis transmembrane conductance regulator constructs regulates channel gating and curcumin potentiation. FEBS J. 2016 Jul;283(13):2458-75. doi: 10.1111/febs.13752. Epub 2016 Jun 15

2015 | Wright AB [student], Norimatsu Y, McIntosh JM, Elmslie KS. Limited efficacy of α-conopeptides, Vc1.1 and RgIA, to inhibit sensory neuron CaV current. eNeuro. 2015;2(1).

2013 | Moran AR, Norimatsu Y, Dawson DC, Macdonald KD. Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L284-91. doi:10.1152/ajplung.00163.2013. Epub 2013 Dec 6

2014 | Reese EA, Norimatsu Y, Grandy MS, Suchland KL, Bunzow JR, Grandy DK. Exploring the Determinants of Trace Amine-Associated Receptor 1's Functional Selectivity for the Stereoisomers of Amphetamine and Methamphetamine. J Med Chem. 2014 Jan 23;57(2):378-90. doi: 10.1021/jm401316v. Epub 2014 Jan 7

2012 | Norimatsu Y, Ivetac A, Alexander C, O'Donnell N, Frye L, Sansom MS, Dawson DC. Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol Pharmacol. 2012 Dec;82(6):1042-55. doi: 10.1124/mol.112.080267. Epub 2012 Aug 24

2012 | Norimatsu Y, Ivetac A, Alexander C, Kirkham J, O'Donnell N, Dawson DC, Sansom MS. Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a bottleneck in the pore. Biochemistry. 2012 Mar 20;51(11):2199-212. doi: 10.1021/bi201888a. Epub 2012 Mar 7.

2012 | Norimatsu Y, Moran AR, MacDonald KD. Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP(4)). Biochem Biophys Res Commun. 2012 Sep 28;426(3):374-9. doi: 10.1016/j.bbrc.2012.08.097. Epub 2012 Aug 29

2009 | Alexander C, Ivetac A, Liu X, Norimatsu Y, Serrano JR, Landstrom A, Sansom M, Dawson DC. Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore. Biochemistry. 2009 Oct 27;48(42):10078-88. doi: 10.1021/bi901314c

1998 | Bull NJ, Milbus AC, Norimatsu Y, Jarmyn BL, Schwarz MP. Giving your daughters the edge: Bequeathing reproductive dominannce in a primatively social bee. Proc Royal Soc London (Series B) 1998 Aug;265:1411-5.

2005 | PhD Thesis: Norimatsu Y. Ion channels in the plasma membrane of barley leaf cells and their response to the fungal pathogen, Rhynchosporium secalis. 2005. Flinders University Library.

Presentations and Published Abstracts:

2016 | Castellanos M [student], Norimatsu Y. Refining a Molecular Model for the Trace Amine Associated Receptor 1. Poster presented the Truman State University Student Research Conference, Kirksville, MO, April 19, 2016.

2016 | Darkwa L, Norimatsu Y. Investigating Modulators of the Protein Kinase R-like ER kinase (PERK) Pathway of the ER Stress Response. Poster presented at TruScholars Research Symposium, Kirksville, MO, August 27, 2016, and at the 8th Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; November 5, 2016.