James Cox, PhD



Work: 660.626.2348
Fax: 660.626.2981
Email Address: jcox@atsu.edu

Research Interests: Dr. Cox's research is directed at understanding the biochemistry of cancer invasion in the body. He is studying the molecular biology of inhibitors of proteases, proteins important in controlling the spread of cancer cells from a tumor. The structure and genetics of these inhibitor proteins are being examined in cancer cells so that their potential as natural anticancer agents can be determined.

Education:

PhD - University of South Dakota School of Medicine (1984)

Scholarly Activity

Research Publications:

2016 | Cox JL, McIntire S [student]. The effects of cystatin C construct clones on B16F10 in vitro cell behavior. J Mol Biochem. 2016;5(1):4-11

2015 | Cox JL, Chang Y, Ramaraj P. In-Vitro determination of biological and anabolic functions of weak androgen dehydroepiandrosterone (DHEA) using a variety of cell lines. Open J Endocr Metab Dis, 2015, 5(8) 105-116

2014 | Ramaraj P, Cox J. In-vitro effect of sex steroids on mouse melanoma (B16F10) cell growth. CellBio, 2014. 3(2):60-71. doi: 10.4236/cellbio.2014.32007

2014 | Ahmad Z, Cox JL. ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine. ScientificWorldJournal. 2014 Jan 29;2014:567398. eCollection 2014. Review

2013 | Deady L [Student]. Cox JL. Uptake of cystatin by melanoma cells in culture. CellBio 2013;2:64-69

2009 | Dowling S, Cox J, Cenedella RJ. Inhibition of fatty acid synthase by orlistat accelerates gastric tumor cell apoptosis in culture and increases survival rates in gastric tumor bearing mice in vivo. Lipids. 2009 Jun;44(6):489-98. Epub 2009 Apr 21

2009 | Cox, JL, Cystatins and cancer, Front Biosci. 2009 Jan 1;14:463-74

2007 | Yang Z, Cox JL. Cathepsin L increases invasion and migration of B16 melanoma. Cancer Cell Int. 2007 May 8;7:8

2005 | Ervin H, Cox JL. Late stage inhibition of hematogenous melanoma metastasis by cystatin C over-expression. Cancer Cell Int. 2005 May 17;5(1):14

2002 | Cox JL, Lancaster T, Carlson CG. Changes in the motility of B16F10 melanoma cells induced by alterations in resting calcium influx. Melanoma Res. 2002 Jun; 12(3):211-9

1999 | Cox JL, Sexton PS, Green TJ, Darmani NA. Inhibition of B16 melanoma metastasis by overexpression of the cysteine proteinase inhibitor cystatin C. Melanoma Res 1999 Aug;9(4):369-74

1997 | Sexton PS, Cox JL. Inhibition of motility and invasion of B16 melanoma by the overexpression of cystatin C. Melanoma Res 1997 Apr;7(2):97-101

1993 | Munce DB, Cox JL, Small GD, Vlcek D, Pokstavkova S, Miadokova E. Genetic and Biochemical Analysis of Photolyase Mutants of Chlamydomonas reinhardtii. Folia Microbiol 1993 38 (6), 435-440

1993 | Cox JL, Mitchell J. A Laboratory Exercise Designed to Introduce Medical Students to Restriction Enzymes. Biochemical Education 1993 21 (2): 107-108

1992 | Cox JL, Shaw PA. Structure, organization and regulation of a rat cysteine proteinase inhibitor-encoding gene. Gene 1992 Jan 15;110(2):175-80

1991 | Coppola G, Huang F, Riley J, Cox JL, Hantzopoulos P, Zhou LB, Calhoun DH. Sequence and transcriptional activity of the Escherichia coli K-12 chromosome region between rrnC and ilvGMEDA. Gene 1991 Jan 2;97(1):21-7

1990 | Shaw PA, Barka T, Woodin A, Schacter BS, Cox JL. Expression and induction by beta-adrenergic agonists of the cystatin S gene in submandibular glands of developing rats. Biochem J 1990 Jan 1;265(1):115-20

1989 | Garcia T, Sanchez M, Cox JL, Shaw PA, Ross JB, Lehrer S, Schachter B. Identification of a variant form of the human estrogen receptor with an amino acid replacement. Nucleic Acids Res 1989 Oct 5;17(20):8364

1988 | Shaw PA, Cox JL, Barka T, Naito Y. Cloning and sequencing of cDNA encoding a rat salivary cysteine proteinase inhibitor inducible by beta-adrenergic agonists. J Biol Chem 1988 Dec 5;263(34):18133-7

1987 | Cox JL, Cox BJ, Fidanza V, Calhoun DH. The complete nucleotide sequence of the ilvGMEDA cluster of Escherichia coli K-12. Gene 1987;56(2-3):185-98

1985 | Cox JL, Small GD. Isolation of a Photoreactivation-deficient Mutant of Chlamydomonas. Mutation Research 1985 146: 249-255

1984 | Cox JL (Ph.D. Thesis). DNA repair studies using photoreactivation and dark repair mutants of Chlamydomonas reinhardi. University of South Dakota School of Medicine. 1984

Presentations and Published Abstracts:

2015 | Baer R, Ramaraj P, Cox J, Cleaver L. Four talks: Signaling Disruption in Melanoma (Baer R); Difference between Males and Females in Melanoma (Ramaraj P); Progress in Melanoma Therapies (Cox J); Clinical Trials and Clinical Case Discussion (Cleaver L). Oral presentations at the 1st Melanoma Symposium, ATSU-KCOM; Kirksville, MO, May 15, 2015

2014 | McIntire S [student]*, Cox JL. Effect on cystatin C construct clones on B16 melanoma in vitro cell behavior. Poster presented at: 2014 American Society for Cell Biology/International Federation for Cell Biology Meeting; December 6-10, 2014; Philadelphia, PA. Abstract published in: Mol Biol Cell. 2014;25(25):3987(P1881).

2014 | McIntire SL [student], Cox JL. Effects of Cystatin C Variant Clones on B16F10 Metastasis. Poster presented at the 3rd Annual Missouri Osteopathic Student and Post-graduate Research Symposium; Missouri Osteopathic Annual Convention; Branson, MO; April 30-May 4, 2014

2013 | Ramaraj P, Chang Y, Cox JL. In-Vitro Determination of Biological and Anabolic Functions of Weak Androgen Dehydroepiandrosterone (DHEA) Using a Variety of Cell Lines. Meeting abstract published at Endocrine Rev 2013; 34 (03_Meeting/Abstracts): SAT-352. Poster presented at the 95th annual Endocrine-Society Meeting; San Francisco, CA; June 15, 2013

2012 | Cox JL. Cystatins as Inhibitors of Metastatic Disease. Presented at: 2nd World Congress on Cancer Science and Therapy; September 10-12, 2012; San Antonio, TX

2012 | Ramaraj P, Cox JL. Effect of Progesterone on Melanoma Cell Growth. Poster presented at the 94th Annual Meeting of The Endocrine Society, Houston, TX; June 23-26, 2012

2012 | Ramaraj P, Leder DC [student], Cox JL. Effect of Progesterone on In-Vitro Functions of Human Melanoma (BLM) Cells. Poster presented at 4th Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; September 29, 2012

2011 | Ramaraj P, Cox JL. Effect of steroids on in-vitro melanoma cell growth and viability. Endocrine Reviews, 12 (3), P1-29 abstract, June 2011. Poster presentation at the 93rd annual endocrine society meeting at Boston, June 4-7, 2011

2011 | Ramaraj P, Brown J [student], Cox JL. Effect of Progesterone Treatment on Melanoma Cell Growth and Adhesion. Poster presented at 3rd Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; October 22, 2011

2010 | Cox JL, Ramaraj P. Effect of mifepristone (RU-486) on in-vitro melanoma cell growth and viability Mol. Biol. Cell 21 (supplement) Abstract no. 655, December 2010; Poster presented at: 50th annual Society for Cell Biology meeting, Philadelphia, Dec 10-15, 2010

2010 | Ramaraj P, Cox JL. Effect of Mifepristone (RU-486) on In-vitro Melanoma Cell Growth and Viability. Poster presented at 2nd Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; October 9, 2010

2010 | Thompson J [student], Cox J. Comparison of Migration and Flattening between rhoA and cystatin C Overexpressing Tumor Cells. Poster presented at 2nd Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; October 9, 2010

2009 | Cox JL, Deady L [student]. Uptake of Cystatin by Murine Melanoma Cells. Abstract presented at: 49th Annual Meeting of the American Society for Cell Biology; San Diego, CA; December 5-9, 2009

2001 | Ervin H, Cox JL. Cystatin C - Green Fluorescent Protein Fusion Expression in B16f10 Melanoma; AACR; San Francisco, CA; Apr. 6-10, 2001

2000 | Cox JL, Ervin H, Fellows SP. Fusion of Cystatin C to Green Fluorescent Protein Inhibits in vitro Invasion and Motility of B16 Melanoma Cells; ASCB; San Francisco, CA; Dec. 9, 2000

1999 | Carlson CG, Lancaster T, Cox JL. 1999. Metal Antagonists of Resting Calcium Influx Pathways Inhibit the Motility of B16F10 Melanoma Cells. Molecular Biology of the Cell 10:1516

1999 | Cox JL. Cysteine Proteinase Inhibitors and Tumor Metastasis; University of Kansas City School of Medicine; Nov. 2, 1999

1998 | Cox JL. 1998. Cystatin C Overexpression Inhibits the Metastasis of B16 Melanoma. IIV International Metastasis Society Meeting (San Diego, CA)

1998 | Cox, James L., Ph.D: Cystatins and tumor metastasis (CME); KCOM; Lake of the Ozarks, MO; June 20, 1998

1997 | Cox JL. Metastasis and B16 Melanoma; Truman State University; Mar. 14, 1997