The KCOM campus has grown over its more than 100-year history to accomodate the increasing demands of a 21st century medical education. It features a human patient simulation lab, study rooms for standardized patient encounters, classrooms, and labs. It also houses the Gutensohn Clinic, the Still National Osteopathic Museum, the A.T. Still Memorial Library, the Northeast Missouri Area Health Education Center, and the A.T. Still Research Institute. Also on the campus grounds are the Senior Living Campus, Northeast Regional Medical Center, and the George Rea Cancer Center.
KCOM completed construction on the Connell Information Technologies Center in September 2007.The Connell Center houses six human patient simulators in a state-of-the-art simulation lab, expanded library and OMM lab space, classrooms, and study rooms.