School of Osteopathic Medicine in Arizona
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Faculty : Employment Opportunities

Dr. Yen-Ping Kuo


Yen-Ping Kuo, Ph.D.
Phone: (480) 219 - 6076

Dr. Yen-Ping Kuo received her B.S. in Medical Technology from National Taiwan University in her native country of Taiwan. She then received an M.S. in Clinical Laboratory Science from Michigan State University. After completing her Ph.D. training with Charles J. Daniels in Microbiology and Molecular Biology from The Ohio State University in 1997, Dr. Kuo joined Barrow Neurological Institute (BNI) in Phoenix as a post-doctoral fellow in Molecular Neuroscience and was promoted to a research associate in 2002. Her research in association with Dr. Ronald J. Lukas at BNI focused on elucidating the differential gene expression of nicotinic acetylcholine receptors (nAChR) and the roles of nAChR in neuro-immune modulation. Dr. Kuo also has broad academics interest shaped by her earlier research experiences in the areas of Hematology and Molecular Microbiology.

Dr. Kuo's passion for teaching brought her to SOMA in January of 2008. Her educational goal is to inspire life-long learners who strive for excellence. Aside from her primary research published in international journals, Dr. Kuo has been an invited speaker at international conferences and education workshops.

Selected Publications:
Shi, F-D., Kuo, Y-P., Campagnolo, D., Vollmer, T. L., and Lukas, R. J. (2009) Nicotinic Attenuation of Central Nervous System Inflammation and Autoimmunity. J of Immunology, 182, 1730 -1739.

Wu, J., Liu, Q., Yu, K., Hu, J., Kuo, Y-P., Segerberg, M., St. John, P., and Lukas, R. J. (2006) Roles of nicotinic acetylcholine receptor b subunits in functional properties of human a4-containing nicotinic receptors. J Physiol  576: 101-118.

Kuo, Y-P., Xu, L., Eaton, J.B., Zhao, L., Wu, J., and Lukas, R. J. (2005) Roles for nicotinic acetylcholine receptor subunit large cytoplasmic loop sequences in receptor expression and function. J Pharm Exper Thera,  314(1):455–466.

Wu, J., Kuo, Y-P., George, A., Xu, L., Hu, J., and Lukas, R.J. (2004) Amyloid directly inhibits human a4b2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 Cells. J Biol Chem, 279(36): 37842–37851.

Eaton, J.B., Peng, J-H., Schroeder, K.M., George, A.A., Fryer, J.D., Krishnan, C., Buhlman, L., Kuo, Y-P., Steilein, O., and Lukas, R.J.  (2003) Characterization of human a4b2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells.  Mol Pharmacol 64 (6):1283-94.

Zhao, L., Kuo, Y-P., George, A.A., Peng, J-H., Purandare, M.S., Schroeder, K.M., Lukas, R.J., and Wu, J. (2003)  Functional properties of homomeric, human a7-icotinic acetylcholine receptors heterologously expressed in the SH-EP1 human epithelial cell line.  J Pharm Exper Thera 305(3):1132-1141.

Kuo, Y-P., Lucero, L., Michaels, J., DeLuca, D., and Lukas, R.J.  (2002)  Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus.  J Neuroimmunol, 130(1-2):140.

Newman, M.B., Kuo, Y-P. (co-first author), Lukas, R.J., Shytle, R.D., Sanberg, P.R., McGrogan, M.P., and Zigova, T.  (2002)  Nicotinic acetylcholine receptors on NT2 precursor cells and hNT (NT2-N) neurons.  Dev Brain Res 139(1):73-86.

Houlihan, L.M., Slater, E.Y., Guerra, D.L., Peng, J-H., Kuo, Y-P., Lukas, R.J., Cassels, B.K., and Bermudez, I.  (2001)  Activity of cytisine and its brominated isosteres on recombinant human a7, a4b2 and a4b4 nicotinic acetylcholine receptors.  J Neurochem 78, 5, 1029-1043.

Newman, M.B., Zigova, T., Kuo, Y-P., Lukas, R.J., McGrogan, M., Shytle, R.D., Snable, G.I., and Sanberg, P.R.  (2001)  A human neuronal cell line (hNT neuron) for characterizing novel medications targeting nicotinic acetylcholine receptors.  Proc Am Col Neuropsychopharm.

Kuo, Y-P., Thompson, D.K., St. Jean, A., Charlebois, R.L., and Daniels, C. J.  (1997)  Characterization of two heat shock genes from Haloferax volcanii: A model system for transcription regulation in the Archaea.  J Bact 179, 6318-6324.

Nieuwlandt, D.T., Palmer, J.R., Armbruster, D.W., Kuo, Y-P., Oda, W., and Daniels, C.J.  (1995)  A Rapid Procedure for the Isolation of RNA from Haloferax volcanii. Archaea: A Laboratory Manual; Cold Spring Harbor Press pp. 161-162.