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Center for Mechanistic studies

Cyclic pressure on in vitro models of posttraumatic osteoarthritis

 

SRI Scientists

  • Kevin Marberry, MD
  • Rachel Ruhlen, PhD

Purpose

This study aims to test the effect of cyclic and acyclic forces on collagen secretion, chondrocyte viability, and apoptosis of chondrocytes in vitro.

 

Aims

  1. Initial experiments will be performed in the cell line to learn how to isolate and culture primary chondrocytes isolated from rat cartilage.
  2. Chondrocytes isolated from rat knee joints injured using the drop tower device will be cultured and subjected to mild cyclic pressure with the goal of improving chondrocyte functionality.