Kirksville College of Osteopathic Medicine
Apply to ATSU Now
KCOM Student

Faculty and Staff

Scholarly Activity Home | List of Authors | Publications | Presentations & Abstracts
Professional Presentations e.g., CME | Grants Funded | Honors & Recognition

Publications of Keith S. Elmslie, PhD

52. Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y, Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC [student], Elmslie KS, Craik DJ, McIntosh JM. Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4026-35. doi: 10.1073/pnas.1503617112. Epub 2015 Jul 13. PubMed
51. Wright AB [student], Norimatsu Y, McIntosh JM, Elmslie KS. Limited efficacy of α-conopeptides, Vc1.1 and RgIA, to inhibit sensory neuron CaV current. eNeuro. 2015;2(1).
50. Buraei Z, Lee HK, Elmslie KS. Single channel measurements demonstrate the voltage dependence of permeation through N-type and L-type CaV channels. Channels (Austin). 2015 Jan 2;9(1):50-5. doi: 10.4161/19336950.2014.991606. PubMed
49. Buraei Z, Liang H, Elmslie KS. Voltage control of Ca2+ permeation through N-type calcium (CaV2.2) channels. J Gen Physiol. 2014 Sep;144(3):207-20. doi:10.1085/jgp.201411201. Epub 2014 Aug 11. PubMed
48. Baxter JC [student], Ramachandra R [post-doc], Mayne DR [sstudent], Elmslie KS. Functional Expression of α7 Nicotinic Acetylcholine Receptors by Muscle Afferent Neurons. J Neurophysiol. 2014 Jun 25; 112:1549-1558. pii: jn.00035.2014. [Epub ahead of print] PubMed

Ramachandra R [post-doc], McGrew S, Elmslie K. Identification of specific sensory neuron populations for study of expressed ion channels. J Vis Exp. 2013 Dec

24;(82):50782. doi: 10.3791/50782. PubMed
46. Ramachandra R [post-doc], Hassan B, McGrew SG, Dompor J [student], Farrag M, Ruiz-Velasco V, Elmslie KS. Identification of CaV channel types expressed in muscle afferent neurons.J Neurophysiol. 2013 Oct;110(7):1535-43. doi: 10.1152/jn.00069.2013. Epub 2013 Jul 10. PubMed
45. Ramachandra R [post-doc], McGrew SY, Baxter JC [student], Howard JR [student], Elmslie KS. NaV1.8 channels are expressed in large, as well as small, diameter sensory afferent neurons. Channels (Austin). 2013 Jan 1;7(1):34-7. doi: 10.4161/chan.22445. Epub 2012 Oct 12. PubMed
44. Ramachandra R [post-doc], McGrew SY, Baxter JC [student],, Kiveric E [Student],, Elmslie KS. Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons. J Neurophysiol. 2012 Oct;108(8):2230-41. doi: 10.1152/jn.00219.2012. Epub 2012 Aug 1. PubMed
43. Gowd KH, Blais KD [student],, Elmslie KS, Steiner AM, Olivera BM, Bulaj G. Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs. Biopolymers. 2012;98(3):212-23. doi: 10.1002/bip.22047. PubMed
42. Yarotskyy V, Gao G, Peterson BZ, Elmslie KS. Domain III regulates N-type (CaV2.2) calcium channel closing kinetics. J Neurophysiol. 2012 Apr;107(7):1942-51. Epub 2011 Dec 28. PubMed
41. Yarotskyy V, Elmslie KS. Roscovitine inhibits CaV3.1 (T-type) channels by preferentially affecting closed-state inactivation. J Pharmacol Exp Ther. 2012 Feb;340(2):463-72. Epub 2011 Nov 16. PubMed
40. Fassl J, High KM, Stephenson ER, Yarotskyy V, Elmslie KS. The intravenous anesthetic propofol inhibits human L-Type calcium channels by enhancing voltage-dependent inactivation. J Clin Pharmacol. 2011 May;51(5):719-30; 2010 Jun 14. [Epub ahead of print] PubMed
Yarotskyy V, Elmslie KS. Interference between two modulators of N-type (CaV2.2) calcium channel gating demonstrates that omega-conotoxin GVIA disrupts open state gating. Biochim Biophys Acta. 2010 Sep;1798(9):1821-1828. Epub 2010 May 13. PubMed
Ganapathi SB, Fox TE, Kester M, Elmslie KS. Ceramide modulates HERG potassium channel gating by translocation into lipid rafts. Am J Physiol Cell Physiol. 2010 Jul;299(1):C74-86. Epub 2010 Apr 7. PubMed
Guo K, Wang X, Gao G, Huang C, Elmslie KS, Peterson BZ. Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1203-11. Epub 2010 Aug 18. PubMed.

Wang X, Gao G, Guo K, Yarotskyy V, Huang C, Elmslie KS, Peterson BZ.

Phospholemman modulates the gating of cardiac L-type calcium channels. Biophys J. 2010 Apr 7;98(7):1149-59. PubMed

Gowd KH, Yarotskyy V, Elmslie KS, Skalicky JJ, Olivera BM, Bulaj G. Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. Biochemistry. 2010 Mar 30;49(12):2741-52. PubMed


Li Z, Wang X, Gao G, Qu D, Yu B, Huang C, Elmslie KS, Peterson BZ. A single amino acid change in Ca(v)1.2 channels eliminates the permeation and gating differences between Ca(2+) and Ba(2+). J Membr Biol. 2010 Feb;233(1-3):23-33. Epub 2010 Jan 23. PubMed


Yarotskyy V, Gao G, Du L, Ganapathi SB, Peterson BZ, Elmslie KS. Roscovitine
binds to novel L-channel (CaV1.2) sites that separately affect activation and

inactivation. J Biol Chem. 2010 Jan 1;285(1):43-53. PubMed

Yarotskyy V, Elmslie KS. Open-state occupancy prevents gating charge
relaxation of N-type (CaV2.2) calcium channels. Biophys J. 2009 Nov

4;97(9):2446-55. PubMed

Ganapathi SB, Kester M, Elmslie KS. State-dependent block of HERG potassium
channels by R-roscovitine: implications for cancer therapy. Am J Physiol Cell

Physiol. 2009 Apr;296(4):C701-10. PubMed

Yarotskyy V, Gao G, Peterson BZ, Elmslie KS. The Timothy syndrome mutation of
cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and
pharmacological restoration of inactivation. J Physiol. 2009 Feb 1;587(Pt

3):551-65. PubMed

Yarotskyy V, Elmslie KS. omega-conotoxin GVIA alters gating charge movement of
N-type (CaV2.2) calcium channels. J Neurophysiol. 2009 Jan;101(1):332-40. PubMed


Buraei Z, Elmslie KS. The separation of antagonist from agonist effects of
trisubstituted purines on CaV2.2 (N-type) channels. J Neurochem. 2008

May;105(4):1450-61. PubMed

Yarotskyy V, Elmslie KS. Roscovitine, a cyclin-dependent kinase inhibitor,
affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium

channels. Br J Pharmacol. 2007 Oct;152(3):386-95. PubMed

Buraei Z, Schofield G, Elmslie KS. Roscovitine differentially affects CaV2 and
Kv channels by binding to the open state. Neuropharmacology. 2007

Mar;52(3):883-94. PubMed

Goo YS, Lim W, Elmslie KS. Ca2+ enhances U-type inactivation of N-type
(CaV2.2) calcium current in rat sympathetic neurons. J Neurophysiol. 2006

Sep;96(3):1075-83. PubMed

Buraei Z, Anghelescu M, Elmslie KS. Slowed N-type calcium channel (CaV2.2)
deactivation by the cyclin-dependent kinase inhibitor roscovitine. Biophys J.

2005 Sep;89(3):1681-91. PubMed

Elmslie KS. Neurotransmitter modulation of neuronal calcium channels. J

Bioenerg Biomembr. 2003 Dec;35(6):477-89. PubMed

Elmslie KS. Calcium channel blockers in the treatment of disease. J Neurosci

Res. 2004 Mar 15;75(6):733-41. PubMed

Liang H, Elmslie KS. Rapid and reversible block of N-type calcium channels
(CaV 2.2) by omega-conotoxin GVIA in the absence of divalent cations. J Neurosci.

2002 Oct 15;22(20):8884-90. PubMed

Liang H, Elmslie KS. E(f)-current contributes to whole-cell calcium current
in low calcium in frog sympathetic neurons. J Neurophysiol. 2001

Sep;86(3):1156-63. PubMed
Elmslie KS. N-type Calcium Channels. Korean J. Physiol. Pharmacol. 2000. 4:427-437 Abstract
Goo YS, Elmslie KS. Role of protein kinase C on norepinephrine induced inhibition of calcium current in rat sympathetic neurons. Kor. J. Med. Physics. 2000. 11:29-38

Lee HK, Elmslie KS. Reluctant gating of single N-type calcium channels during
neurotransmitter-induced inhibition in bullfrog sympathetic neurons. J Neurosci.

2000 May 1;20(9):3115-28. PubMed

Lee HK, Liu L, Elmslie KS. Effect of high Ba(2+) on norepinephrine-induced
inhibition of N-type calcium current in bullfrog sympathetic neurons. J

Neurophysiol. 2000 Feb;83(2):791-5. PubMed

Lee HK, Elmslie KS. Gating of single N-type calcium channels recorded from
bullfrog sympathetic neurons. J Gen Physiol. 1999 Jan;113(1):111-24. PubMed PMID:

9874692; PubMed

Elmslie KS. Identification of the single channels that underlie the N-type
and L-type calcium currents in bullfrog sympathetic neurons. J Neurosci. 1997 Apr

15;17(8):2658-68. PubMed

Jones SW, Elmslie KS. Transmitter modulation of neuronal calcium channels. J

Membr Biol. 1997 Jan 1;155(1):1-10. Review. PubMed

Ehrlich I, Elmslie KS. Neurotransmitters acting via different G proteins
inhibit N-type calcium current by an identical mechanism in rat sympathetic

neurons. J Neurophysiol. 1995 Dec;74(6):2251-7. PubMed

Elmslie KS, Jones SW. Concentration dependence of neurotransmitter effects on
calcium current kinetics in frog sympathetic neurones. J Physiol. 1994 Nov 15;481

( Pt 1):35-46. PubMed

Elmslie KS, Kammermeier PJ, Jones SW. Reevaluation of Ca2+ channel types and
their modulation in bullfrog sympathetic neurons. Neuron. 1994 Jul;13(1):217-28.


Werz MA, Elmslie KS, Jones SW. Phosphorylation enhances inactivation of
N-type calcium channel current in bullfrog sympathetic neurons. Pflugers Arch.

1993 Sep;424(5-6):538-45. PubMed

van Lunteren E, Elmslie KS, Jones SW. Effects of temperature on calcium
current of bullfrog sympathetic neurons. J Physiol. 1993 Jul;466:81-93. PubMed


Elmslie KS, Werz MA, Overholt JL, Jones SW. Intracellular ATP and GTP are
both required to preserve modulation of N-type calcium channel current by

norepinephrine. Pflugers Arch. 1993 Jun;423(5-6):472-9. PubMed

Elmslie KS, Kammermeier PJ, Jones SW. Calcium current modulation in frog
sympathetic neurones: L-current is relatively insensitive to neurotransmitters. J

Physiol. 1992 Oct;456:107-23. PubMed

Elmslie KS. Calcium current modulation in frog sympathetic neurones: multiple

neurotransmitters and G proteins. J Physiol. 1992;451:229-46. PubMed

Jones SW, Elmslie KS. Separation and modulation of calcium currents in
bullfrog sympathetic neurons. Can J Physiol Pharmacol. 1992;70 Suppl:S56-63.

Review. PubMed

Elmslie KS, Zhou W, Jones SW. LHRH and GTP-gamma-S modify calcium current

activation in bullfrog sympathetic neurons. Neuron. 1990 Jul;5(1):75-80. PubMed

Elmslie KS, Cohen DH. Iontophoresis of norepinephrine onto neurons of the
pigeon's lateral geniculate nucleus: characterization of an inhibitory response.

Brain Res. 1990 May 28;517(1-2):134-42. PubMed

Elmslie KS, Yoshikami D. Effects of kynurenate on root potentials evoked by
synaptic activity and amino acids in the frog spinal cord. Brain Res. 1985 Mar

25;330(2):265-72. PubMed
Book Chapters Return to top
Elmslie KS. Passive Propagation of Electrical Signals. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester. [doi:10.1038/npg.els.0000197] 2005
Elmslie KS. Membrane Potential. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester. [doi:10.1038/npg.els.0000182] 2000
Elmslie KS. Action Potential: Ionic Mechanisms. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester. [doi:10.1038/npg.els.0000002] 2000.