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Publications of Keith S. Elmslie, PhD

51. Wright AB [student], Norimatsu Y, McIntosh JM, Elmslie KS. Limited efficacy of α-conopeptides, Vc1.1 and RgIA, to inhibit sensory neuron CaV current. eNeuro. 2015;2(1).
50. Buraei Z, Lee HK, Elmslie KS. Single channel measurements demonstrate the voltage dependence of permeation through N-type and L-type CaV channels. Channels (Austin). 2015 Jan 2;9(1):50-5. doi: 10.4161/19336950.2014.991606. PubMed
49. Buraei Z, Liang H, Elmslie KS. Voltage control of Ca2+ permeation through N-type calcium (CaV2.2) channels. J Gen Physiol. 2014 Sep;144(3):207-20. doi:10.1085/jgp.201411201. Epub 2014 Aug 11. PubMed
48. Baxter JC [student], Ramachandra R [post-doc], Mayne DR [sstudent], Elmslie KS. Functional Expression of α7 Nicotinic Acetylcholine Receptors by Muscle Afferent Neurons. J Neurophysiol. 2014 Jun 25; 112:1549-1558. pii: jn.00035.2014. [Epub ahead of print] PubMed

Ramachandra R [post-doc], McGrew S, Elmslie K. Identification of specific sensory neuron populations for study of expressed ion channels. J Vis Exp. 2013 Dec

24;(82):50782. doi: 10.3791/50782. PubMed
46. Ramachandra R [post-doc], Hassan B, McGrew SG, Dompor J [student], Farrag M, Ruiz-Velasco V, Elmslie KS. Identification of CaV channel types expressed in muscle afferent neurons.J Neurophysiol. 2013 Oct;110(7):1535-43. doi: 10.1152/jn.00069.2013. Epub 2013 Jul 10. PubMed
45. Ramachandra R [post-doc], McGrew SY, Baxter JC [student], Howard JR [student], Elmslie KS. NaV1.8 channels are expressed in large, as well as small, diameter sensory afferent neurons. Channels (Austin). 2013 Jan 1;7(1):34-7. doi: 10.4161/chan.22445. Epub 2012 Oct 12. PubMed
44. Ramachandra R [post-doc], McGrew SY, Baxter JC [student],, Kiveric E [Student],, Elmslie KS. Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons. J Neurophysiol. 2012 Oct;108(8):2230-41. doi: 10.1152/jn.00219.2012. Epub 2012 Aug 1. PubMed
43. Gowd KH, Blais KD [student],, Elmslie KS, Steiner AM, Olivera BM, Bulaj G. Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs. Biopolymers. 2012;98(3):212-23. doi: 10.1002/bip.22047. PubMed
42. Yarotskyy V, Gao G, Peterson BZ, Elmslie KS. Domain III regulates N-type (CaV2.2) calcium channel closing kinetics. J Neurophysiol. 2012 Apr;107(7):1942-51. Epub 2011 Dec 28. PubMed
41. Yarotskyy V, Elmslie KS. Roscovitine inhibits CaV3.1 (T-type) channels by preferentially affecting closed-state inactivation. J Pharmacol Exp Ther. 2012 Feb;340(2):463-72. Epub 2011 Nov 16. PubMed
40. Fassl J, High KM, Stephenson ER, Yarotskyy V, Elmslie KS. The intravenous anesthetic propofol inhibits human L-Type calcium channels by enhancing voltage-dependent inactivation. J Clin Pharmacol. 2011 May;51(5):719-30; 2010 Jun 14. [Epub ahead of print] PubMed
Yarotskyy V, Elmslie KS. Interference between two modulators of N-type (CaV2.2) calcium channel gating demonstrates that omega-conotoxin GVIA disrupts open state gating. Biochim Biophys Acta. 2010 Sep;1798(9):1821-1828. Epub 2010 May 13. PubMed
Ganapathi SB, Fox TE, Kester M, Elmslie KS. Ceramide modulates HERG potassium channel gating by translocation into lipid rafts. Am J Physiol Cell Physiol. 2010 Jul;299(1):C74-86. Epub 2010 Apr 7. PubMed
Guo K, Wang X, Gao G, Huang C, Elmslie KS, Peterson BZ. Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1203-11. Epub 2010 Aug 18. PubMed.

Wang X, Gao G, Guo K, Yarotskyy V, Huang C, Elmslie KS, Peterson BZ.

Phospholemman modulates the gating of cardiac L-type calcium channels. Biophys J. 2010 Apr 7;98(7):1149-59. PubMed

Gowd KH, Yarotskyy V, Elmslie KS, Skalicky JJ, Olivera BM, Bulaj G. Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. Biochemistry. 2010 Mar 30;49(12):2741-52. PubMed


Li Z, Wang X, Gao G, Qu D, Yu B, Huang C, Elmslie KS, Peterson BZ. A single amino acid change in Ca(v)1.2 channels eliminates the permeation and gating differences between Ca(2+) and Ba(2+). J Membr Biol. 2010 Feb;233(1-3):23-33. Epub 2010 Jan 23. PubMed


Yarotskyy V, Gao G, Du L, Ganapathi SB, Peterson BZ, Elmslie KS. Roscovitine
binds to novel L-channel (CaV1.2) sites that separately affect activation and

inactivation. J Biol Chem. 2010 Jan 1;285(1):43-53. PubMed

Yarotskyy V, Elmslie KS. Open-state occupancy prevents gating charge
relaxation of N-type (CaV2.2) calcium channels. Biophys J. 2009 Nov

4;97(9):2446-55. PubMed

Ganapathi SB, Kester M, Elmslie KS. State-dependent block of HERG potassium
channels by R-roscovitine: implications for cancer therapy. Am J Physiol Cell

Physiol. 2009 Apr;296(4):C701-10. PubMed

Yarotskyy V, Gao G, Peterson BZ, Elmslie KS. The Timothy syndrome mutation of
cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and
pharmacological restoration of inactivation. J Physiol. 2009 Feb 1;587(Pt

3):551-65. PubMed

Yarotskyy V, Elmslie KS. omega-conotoxin GVIA alters gating charge movement of
N-type (CaV2.2) calcium channels. J Neurophysiol. 2009 Jan;101(1):332-40. PubMed


Buraei Z, Elmslie KS. The separation of antagonist from agonist effects of
trisubstituted purines on CaV2.2 (N-type) channels. J Neurochem. 2008

May;105(4):1450-61. PubMed

Yarotskyy V, Elmslie KS. Roscovitine, a cyclin-dependent kinase inhibitor,
affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium

channels. Br J Pharmacol. 2007 Oct;152(3):386-95. PubMed

Buraei Z, Schofield G, Elmslie KS. Roscovitine differentially affects CaV2 and
Kv channels by binding to the open state. Neuropharmacology. 2007

Mar;52(3):883-94. PubMed

Goo YS, Lim W, Elmslie KS. Ca2+ enhances U-type inactivation of N-type
(CaV2.2) calcium current in rat sympathetic neurons. J Neurophysiol. 2006

Sep;96(3):1075-83. PubMed

Buraei Z, Anghelescu M, Elmslie KS. Slowed N-type calcium channel (CaV2.2)
deactivation by the cyclin-dependent kinase inhibitor roscovitine. Biophys J.

2005 Sep;89(3):1681-91. PubMed

Elmslie KS. Neurotransmitter modulation of neuronal calcium channels. J

Bioenerg Biomembr. 2003 Dec;35(6):477-89. PubMed

Elmslie KS. Calcium channel blockers in the treatment of disease. J Neurosci

Res. 2004 Mar 15;75(6):733-41. PubMed

Liang H, Elmslie KS. Rapid and reversible block of N-type calcium channels
(CaV 2.2) by omega-conotoxin GVIA in the absence of divalent cations. J Neurosci.

2002 Oct 15;22(20):8884-90. PubMed

Liang H, Elmslie KS. E(f)-current contributes to whole-cell calcium current
in low calcium in frog sympathetic neurons. J Neurophysiol. 2001

Sep;86(3):1156-63. PubMed
Elmslie KS. N-type Calcium Channels. Korean J. Physiol. Pharmacol. 2000. 4:427-437 Abstract
Goo YS, Elmslie KS. Role of protein kinase C on norepinephrine induced inhibition of calcium current in rat sympathetic neurons. Kor. J. Med. Physics. 2000. 11:29-38

Lee HK, Elmslie KS. Reluctant gating of single N-type calcium channels during
neurotransmitter-induced inhibition in bullfrog sympathetic neurons. J Neurosci.

2000 May 1;20(9):3115-28. PubMed

Lee HK, Liu L, Elmslie KS. Effect of high Ba(2+) on norepinephrine-induced
inhibition of N-type calcium current in bullfrog sympathetic neurons. J

Neurophysiol. 2000 Feb;83(2):791-5. PubMed

Lee HK, Elmslie KS. Gating of single N-type calcium channels recorded from
bullfrog sympathetic neurons. J Gen Physiol. 1999 Jan;113(1):111-24. PubMed PMID:

9874692; PubMed

Elmslie KS. Identification of the single channels that underlie the N-type
and L-type calcium currents in bullfrog sympathetic neurons. J Neurosci. 1997 Apr

15;17(8):2658-68. PubMed

Jones SW, Elmslie KS. Transmitter modulation of neuronal calcium channels. J

Membr Biol. 1997 Jan 1;155(1):1-10. Review. PubMed

Ehrlich I, Elmslie KS. Neurotransmitters acting via different G proteins
inhibit N-type calcium current by an identical mechanism in rat sympathetic

neurons. J Neurophysiol. 1995 Dec;74(6):2251-7. PubMed

Elmslie KS, Jones SW. Concentration dependence of neurotransmitter effects on
calcium current kinetics in frog sympathetic neurones. J Physiol. 1994 Nov 15;481

( Pt 1):35-46. PubMed

Elmslie KS, Kammermeier PJ, Jones SW. Reevaluation of Ca2+ channel types and
their modulation in bullfrog sympathetic neurons. Neuron. 1994 Jul;13(1):217-28.


Werz MA, Elmslie KS, Jones SW. Phosphorylation enhances inactivation of
N-type calcium channel current in bullfrog sympathetic neurons. Pflugers Arch.

1993 Sep;424(5-6):538-45. PubMed

van Lunteren E, Elmslie KS, Jones SW. Effects of temperature on calcium
current of bullfrog sympathetic neurons. J Physiol. 1993 Jul;466:81-93. PubMed


Elmslie KS, Werz MA, Overholt JL, Jones SW. Intracellular ATP and GTP are
both required to preserve modulation of N-type calcium channel current by

norepinephrine. Pflugers Arch. 1993 Jun;423(5-6):472-9. PubMed

Elmslie KS, Kammermeier PJ, Jones SW. Calcium current modulation in frog
sympathetic neurones: L-current is relatively insensitive to neurotransmitters. J

Physiol. 1992 Oct;456:107-23. PubMed

Elmslie KS. Calcium current modulation in frog sympathetic neurones: multiple

neurotransmitters and G proteins. J Physiol. 1992;451:229-46. PubMed

Jones SW, Elmslie KS. Separation and modulation of calcium currents in
bullfrog sympathetic neurons. Can J Physiol Pharmacol. 1992;70 Suppl:S56-63.

Review. PubMed

Elmslie KS, Zhou W, Jones SW. LHRH and GTP-gamma-S modify calcium current

activation in bullfrog sympathetic neurons. Neuron. 1990 Jul;5(1):75-80. PubMed

Elmslie KS, Cohen DH. Iontophoresis of norepinephrine onto neurons of the
pigeon's lateral geniculate nucleus: characterization of an inhibitory response.

Brain Res. 1990 May 28;517(1-2):134-42. PubMed

Elmslie KS, Yoshikami D. Effects of kynurenate on root potentials evoked by
synaptic activity and amino acids in the frog spinal cord. Brain Res. 1985 Mar

25;330(2):265-72. PubMed
Book Chapters Return to top
Elmslie KS. Passive Propagation of Electrical Signals. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester. [doi:10.1038/npg.els.0000197] 2005
Elmslie KS. Membrane Potential. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester. [doi:10.1038/npg.els.0000182] 2000
Elmslie KS. Action Potential: Ionic Mechanisms. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester. [doi:10.1038/npg.els.0000002] 2000.