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Publications of Byunghee "Henry" Han, PhD

53. Washington CW, Derdeyn CP, Dhar R, Arias EJ, Chicoine MR, Cross DT, Dacey RG Jr, Han BH, Moran CJ, Rich KM, Vellimana AK, Zipfel GJ. A Phase I proof-of-concept and safety trial of sildenafil to treat cerebral vasospasm following subarachnoid hemorrhage. J Neurosurg. 2016;124(2):318-327. PubMed
52. Reynolds MR, Singh I, Azad TD, Holmes BB, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ. Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells. Mol Neurodegener. 2016 Jan 22;11(1):9. doi: 10.1186/s13024-016-0073-8. PubMed
51. Bales KR, O'Neill SM, Pozdnyakov N, Pan F, Caouette D, Pi Y, Wood KM, Volfson D, Cirrito JR, Han BH, Johnson AW, Zipfel GJ, Samad TA. Passive immunotherapy targeting amyloid-β reduces cerebral amyloid angiopathy and improves vascular reactivity. Brain. 2015 Oct 22. pii: awv313. [Epub ahead of print] PubMed
50. Washington CW, Derdeyn CP, Dhar R, Arias EJ, Chicoine MR, Cross DT, Dacey RG Jr, Han BH, Moran CJ, Rich KM, Vellimana AK, Zipfel GJ. A Phase I proof-of-concept and safety trial of sildenafil to treat cerebral vasospasm following subarachnoid hemorrhage. J Neurosurg. 2015 Aug 28:1-10. [Epub ahead of print] PubMed
49. Han BH, Zhou ML, Johnson AW, Singh I, Liao F, Vellimana AK, Nelson JW, Milner E, Cirrito JR, Basak J, Yoo M, Dietrich HH, Holtzman DM, Zipfel GJ. Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction,and microhemorrhage in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E881-90. doi: 10.1073/pnas.1414930112. Epub 2015 Feb 9. PubMed
48. Lee HJ, Dietrich HH, Han BH, Zipfel GJ. Development of an ex vivo model for the study of cerebrovascular function utilizing isolated mouse olfactory artery. J Korean Neurosurg Soc. 2015 Jan;57(1):1-5. doi: 10.3340/jkns.2015.57.1.1. Epub 2015 Jan 31. PubMed
47. Milner E, Johnson AW, Nelson JW, Harries MD, Gidday JM, Han BH, Zipfel GJ. HIF-1α Mediates Isoflurane-Induced Vascular Protection in Subarachnoid Hemorrhage. Ann Clin Transl Neurol. 2015 Apr;2(4):325-37. doi: 10.1002/acn3.170. Epub 2015 Feb 21. PubMed
46. Kim GS, Cho S, Nelson JW, Zipfel GJ, Han BH. TrkB agonist antibody pretreatment enhances neuronal survival and long-term sensory motor function following hypoxic ischemic injury in neonatal rats. PLoS One. 2014 Feb 14;9(2):e88962. doi: 10.1371/journal.pone.0088962. eCollection 2014. PubMed
45. Milner E, Zhou ML, Johnson AW, Vellimana AK, Greenberg JK, Holtzman DM, Han BH, Zipfel GJ. Cerebral amyloid angiopathy increases susceptibility to infarction after focal cerebral ischemia in Tg2576 mice. Stroke. 2014 Oct;45(10):3064-9. doi: 10.1161/STROKEAHA.114.006078. Epub 2014 Sep 4. PubMed
44. Milner E, Holtzman JC, Friess S, Hartman RE, Brody DL, Han BH, Zipfel GJ. Endovascular perforation subarachnoid hemorrhage fails to cause Morris water maze deficits in the mouse. J Cereb Blood Flow Metab. 2014 Sep;34(9). doi:10.1038/jcbfm.2014.108. Epub 2014 Jun 18. PubMed
43. Johnson AW, Zipfel GJ, Han BH. Editorial: Cerebral Amyloid Angiopathy: Perspectives on cerebrovascular dysfunction, J Neurol Dis. 2013 2:1 Paper
42. Han BH, Vellimana AK, Zhou ML, Milner E, Zipfel GJ. Phosphodiesterase 5 inhibition attenuates cerebral vasospasm and improves functional recovery after experimental subarachnoid hemorrhage. Neurosurgery. 2012 Jan;70(1):178-86;discussion 186-7. doi: 10.1227/NEU.0b013e31822ec2b0. PubMed
41. Han BH, Zhou ML, Vellimana AK, Milner E, Kim DH, Greenberg JK, Chu W, Mach RH, Zipfel GJ. Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy. Mol Neurodegener. 2011 Dec 22;6:86. doi: 10.1186/1750-1326-6-86. PubMed
40. Vellimana AK, Milner E, Azad TD, Harries MD, Zhou ML, Gidday JM, Han BH, Zipfel GJ. Endothelial nitric oxide synthase mediates endogenous protection against subarachnoid hemorrhage-induced cerebral vasospasm. Stroke. 2011 Mar;42(3):776-82. doi: 10.1161/STROKEAHA.110.607200. Epub 2011 Feb 11. PubMed
39. Dietrich HH, Xiang C, Han BH, Zipfel GJ, Holtzman DM. Soluble amyloid-beta, effect on cerebral arteriolar regulation and vascular cells. Mol Neurodegener. 2010 Apr 13;5:15. doi: 10.1186/1750-1326-5-15. PubMed
38. Han BH, Zhou ML, Abousaleh F, Brendza RP, Dietrich HH, Koenigsknecht-Talboo J, Cirrito JR, Milner E, Holtzman DM, Zipfel GJ. Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition. J Neurosci. 2008 Dec 10;28(50):13542-50. doi: 10.1523/JNEUROSCI.4686-08.2008. PubMed
37. Zipfel GJ, Han H, Ford AL, Lee JM. Cerebral amyloid angiopathy: progressive disruption of the neurovascular unit. Stroke. 2009 Mar;40(3 Suppl):S16-9. doi: 10.1161/STROKEAHA.108.533174. Epub 2008 Dec 8. PubMed
36. Wei L, Han BH, Li Y, Keogh CL, Holtzman DM, Yu SP. Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats. J Pharmacol Exp Ther. 2006 Apr;317(1):109-16. Epub 2005 Dec 15. PubMed
35. Park GH, Ryu JR, Shin CY, Choi MS, Han BH, Kim WK, Kim HC, Ko KH. Evidence that protease-activated receptor-2 mediates trypsin-induced reversal of stellation in cultured rat astrocytes. Neurosci Res. 2006 Jan;54(1):15-23. Epub 2005 Oct 26. PubMed
34. Hwang IK, Yoo KY, Kim DW, Kang TC, Choi SY, Kwon YG, Han BH, Kim JS, Won MH. Na+/Ca2+ exchanger 1 alters in pyramidal cells and expresses in astrocytes of the gerbil hippocampal CA1 region after ischemia. Brain Res. 2006 May 1;1086(1):181-90. Epub 2006 Apr 13. PubMed
33. Hwang IK, Yoo KY, Kim DW, Lee BH, Kang TC, Choi SY, Han BH, Kim JS, Won MH. Ischemia-related changes of glial-derived neurotrophic factor and phosphatidylinositol 3-kinase in the hippocampus: their possible correlation in astrocytes. Brain Res. 2006 Feb 9;1072(1):215-23. Epub 2006 Jan 17. PubMed
32. Shin DH, Bae YC, Kim-Han JS, Lee JH, Choi IY, Son KH, Kang SS, Kim WK, Han BH. Polyphenol amentoflavone affords neuroprotection against neonatal hypoxic-ischemic brain damage via multiple mechanisms. J Neurochem. 2006 Jan;96(2):561-72. Epub 2005 Dec 8. PubMed
31. Kim GS, Choi YK, Song SS, Kim WK, Han BH. MKP-1 contributes to oxidative stress-induced apoptosis via inactivation of ERK1/2 in SH-SY5Y cells. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1732-8. Epub 2005 Nov 2. PubMed
30. Kang SS, Lee JY, Choi YK, Song SS, Kim JS, Jeon SJ, Han YN, Son KH, Han BH. Neuroprotective effects of naturally occurring biflavonoids. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3588-91. PubMed
29. Kim SW, Her SJ, Park SJ, Kim D, Park KS, Lee HK, Han BH, Kim MS, Shin CS, Kim SY. Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone. 2005 Sep;37(3):359-69. PubMed
28. Hwang IK, Lee KY, Yoo KY, Kim DS, Lee NS, Jeong YG, Kang TC, Han BH, Kim JS,Won MH. Tyrosine kinase A but not phosphacan/protein tyrosine phosphatase-zeta/beta immunoreactivity and protein level changes in neurons and astrocytes in the gerbil hippocampus proper after transient forebrain ischemia. Brain Res. 2005 Mar 2;1036(1-2):35-41. PubMed
27. Shin H, Hwang IK, Yoo KY, Song JH, Jung JY, Kang TC, Choi SY, Han BH, Kim JS, Won MH. Expression and changes of Ca2+-ATPase in neurons and astrocytes in the gerbil hippocampus after transient forebrain ischemia. Brain Res. 2005 Jul5;1049(1):43-51. PubMed
26. Yoo BK, Choi JW, Han BH, Kim WK, Kim HC, Ko KH. Role of MAPK/ERK1/2 in the glucose deprivation-induced death in immunostimulated astroglia. Neurosci Lett.2005 Mar 16;376(3):171-6. Epub 2004 Dec 19. PubMed
25. Hwang IK, Yoo KY, Kim DW, Han BH, Kang TC, Choi SY, Kim JS, Won MH. Protein disulfide isomerase immunoreactivity and protein level changes in neurons and astrocytes in the gerbil hippocampal CA1 region following transient ischemia. Neurosci Lett. 2005 Feb 28;375(2):117-22. Epub 2004 Dec 10. PubMed
24. Hwang IK, Yoo KY, Kim DS, Do SG, Oh YS, Kang TC, Han BH, Kim JS, Won MH. Expression and changes of galanin in neurons and microglia in the hippocampus after transient forebrain ischemia in gerbils. Brain Res. 2004 Oct 15;1023(2):193-9. PubMed
23. Ju C, Oh YJ, Han BH, Kim HS, Kim HC, Kim WK. Intracellular pH-dependent peroxynitrite-evoked synergistic death of glucose-deprived astrocytes. Free Radic Biol Med. 2004 Oct 15;37(8):1160-9. PubMed
22. Choi WS, Eom DS, Han BS, Kim WK, Han BH, Choi EJ, Oh TH, Markelonis GJ, Cho JW, Oh YJ. Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. J Biol Chem. 2004 May 7;279(19):20451-60. Epub 2004 Mar 1. PubMed
21. Choi JW, Shin CY, Yoo BK, Choi MS, Lee WJ, Han BH, Kim WK, Kim HC, Ko KH. Glucose deprivation increases hydrogen peroxide level in immunostimulated rat primary astrocytes. J Neurosci Res. 2004 Mar 1;75(5):722-31. PubMed
20. Kang SS, Lee JY, Choi YK, Kim GS, Han BH. Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells. Bioorg Med Chem Lett. 2004 May 3;14(9):2261-4. PubMed
19. Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, Holtzman DM, Ferriero DM, Vexler ZS. Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke. 2003 Jan;34(1):207-13. PubMed
18. Hee Han B, Choi J, Holtzman DM. Evidence that p38 mitogen-activated protein kinase contributes to neonatal hypoxic-ischemic brain injury. Dev Neurosci. 2002;24(5):405-10. PubMed
17. Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM. Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol. 2002 Jul;52(1):54-61. PubMed
Han BH, Xu D, Choi J, Han Y, Xanthoudakis S, Roy S, Tam J, Vaillancourt J, Colucci J, Siman R, Giroux A, Robertson GS, Zamboni R, Nicholson DW, Holtzman DM. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury. J Biol Chem. 2002 Aug 16;277(33):30128-36. Epub 2002 Jun 10. PubMed
Back SA, Han BH, Luo NL, Chricton CA, Xanthoudakis S, Tam J, Arvin KL, Holtzman DM. Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. J Neurosci. 2002 Jan 15;22(2):455-63. PubMed
Han BH, DeMattos RB, Dugan LL, Kim-Han JS, Brendza RP, Fryer JD, Kierson M,Cirrito J, Quick K, Harmony JA, Aronow BJ, Holtzman DM. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nat Med. 2001 Mar;7(3):338-43. PubMed
Gibson ME, Han BH, Choi J, Knudson CM, Korsmeyer SJ, Parsadanian M, Holtzman DM. BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways. Mol Med. 2001 Sep;7(9):644-55. PubMed
Holtzman DM, Han BH, He YY, Kim KM, Choi J, Hsu C. Reply to ‘Inhibition of post-ischemic brain injury by clusterin overexpression.' Nat Med 7: 978-979, 2001.
Han BH, Holtzman DM. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci. 2000 Aug 1;20(15):5775-81. PubMed
Almli CR, Levy TJ, Han BH, Shah AR, Gidday JM, Holtzman DM. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Exp Neurol. 2000 Nov;166(1):99-114. PubMed
Lendon CL, Han BH, Salimi K, Fagan AM, Behrens MI, Muller MC, Holtzman DM. No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo. Eur J Neurosci. 2000 Jul;12(7):2235-42. PubMed
Kim HD, Turner JT, Burnett JE, Joo NS, Han BH, Lim RW, Bowen JW, Kirk RG, Lee P. Furosemide stimulates K transport in HCD57 erythroid cells. J Membr Biol. 2000 Jun 1;175(3):235-44. PubMed
Han BH, D'Costa A, Back SA, Parsadanian M, Patel S, Shah AR, Gidday JM, Srinivasan A, Deshmukh M, Holtzman DM. BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia. Neurobiol Dis. 2000 Feb;7(1):38-53. PubMed
Selznick LA, Holtzman DM, Han BH, Gökden M, Srinivasan AN, Johnson EM Jr, Roth KA. In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease. J Neuropathol Exp Neurol. 1999 Sep;58(9):1020-6. PubMed
Joo NS, Clarke LL, Han BH, Forte LR, Kim HD. Cloning of ClC-2 chloride channel from murine duodenum and its presence in CFTR knockout mice. Biochim Biophys Acta. 1999 Sep 3;1446(3):431-7. PubMed
Han BH. Interferon-gamma and lipopolysaccharide induce mouse guanylate-binding protein 3 (mGBP3) expression in the murine macrophage cell line RAW264.7. Arch Pharm Res. 1999 Apr;22(2):130-6. PubMed
Han BH, Park DJ, Lim RW, Im JH, Kim HD. Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells. Biochim Biophys Acta. 1998 May 9;1384(2):373-86. PubMed.
Chen B, Han BH, Sun XH, Lim RW. Inhibition of muscle-specific gene expression by Id3: requirement of the C-terminal region of the protein for stable expression and function. Nucleic Acids Res. 1997 Jan 15;25(2):423-30. PubMed
Lee JW, Han BH, Lee JW, Seok JH, Kim SC, Hong YH, Suh JJ, Hong SU. Antihypertensive and cardiovascular effects of the new calcium antagonist YH334. Arch Pharm Res. 1991 Sep; 14: 242-248 Paper
Poster Presentations/Published Abstracts Return to top


Choi EY, Han BH. Effects of Amentoflavone on the Aggregation and Disaggregation of Amyloid β. Poster presented at the 8th Annual Interdisciplinary Biomedical Research Conference; Kirksville, MO; November 5, 2016.