Kirksville College of Osteopathic Medicine
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William L. Sexton, PhD



Department of Physiology


Address: A.T. Still University of Health Sciences
Kirksville College of Osteopathic Medicine
800 W. Jefferson St.
Kirksville, MO  63501

Postdoctoral Fellowship: University of Missouri, 1988

PhD: Kansas State University, 1985

MS: University of California-Davis, 1979

BS: University of California-Davis, 1977




Research Interests: Dr. Sexton's research concerns the factors controlling oxygen delivery to skeletal muscle, heart and diaphragm. Specifically, how oxygen delivery is matched to oxygen utilization, and how these processes are altered with exercise training and in disease states. Recent studies have focused on diabetes-induced changes in the capillary bed of the skeletal muscle, heart and diaphragm that profoundly impact the ability of the cardiovascular system to supply the tissues with oxygen and nutrients, and the role of exercise in reducing the severity of these diabetes-induced changes. Microvascular oxygen tension is measured in resting and contracting muscle using the phosphorescence quenching method to determine the net balance between oxygen delivery and uptake. Studies are also being conducted to determine the role of vasoactive endothelial growth factor (VEGF) in the decrease in muscle capillarity in diabetes, and how these changes are ameliorated with regular exercise.

List of Publications
Annual lists of Publications, Grants, Abstracts/Presentations and Honors for the ATSU/KCOM faculty are available under Scholarly Activity