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Kirksville College of Osteopathic Medicine
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Master of Biomedical Sciences (M.S.)

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Biomedical Sciences Research Track Catalog : Human Anatomy Education Track Catalog
D.O./M.S. Dual Degree Track : Course Descriptions : Tuition : Research Topics, Publications & Abstracts : Fact Sheet PDF : Request a Tour

Research Topics

See also: Research Publications Involving Graduate Students
See also: Research Abstracts Involving Graduate Students

FACULTY MEMBERS

 

RESEARCH TOPICS

 

Anatomy Department

Peter Kondrashov, Ph.D.

 

pkondrashov@atsu.edu

 

660-626-2771

 

Musculoskeletal adaptations to various modes of locomotion

 

Microstructure of bone using scanning electron microscopy

Edwin Purcell, Ph.D.

 

epurcell@atsu.edu

 

660-626-2217

 

 

Neural influences on immune function

 

Effect of osteopathic manipulation on autonomic function

 

Diana Rhodes, Ph.D.

 

drhodes@atsu.edu

 

660-626-2149

 

 

The biochemical and immunological properties of an abundant urinary protein, Tamm-Horsfall protein

James Rhodes, Ph.D.

 

jrhodes@atsu.edu

 

60-626-2753

Cell-cycle kinetics, in vivo, using mouse skin as a model with the long-term goal of understanding how tissues regulate their size

 

Role of protease and glycosidase activities in human urine and association with interstitial cystitis

 

 


 

 

Biochemistry Department

James Cox, Ph.D.

 

jcox@atsu.edu

 

660-626-2466

 

 

Gene studies in cancer

 

Proteases in tumor metastasis

Richard Fleschner, Ph.D.

 

cfleschner@atsu.edu

 

660-626-2761

 

 

Biochemistry of ocular lens plasma membranes

 

Identification and quantification of various intrinsic and extrinsic proteins associated with various ocular lens membrane fractions using one- and two-dimensional electrophoresis and western blotting

 

 

Pandurangan Ramaraj, Ph.D.

pramaraj@atsu.edu

Hormone-mediated differentiation of murine mesenchymal multipotent cells

Signaling pathways in steroid hormone actions

 

 

 

 

Microbiology and Immunology Department

Neal Chamberlain, Ph.D.


nchamberlain@atsu.edu

 

660-626-2474

 

 

Mechanisms of pathogenicity of Staphylococcus aureus and S. epidermidis

 

Mechanisms of antibiotic survival of S. epidermidis in biofilms

 

 

Neil Sargentini, Ph.D.


nsargentini@atsu.edu

 

660-626-2474

 

 

Genetic regulation associated with osteopathic manipulative medicine in a rat model for nociceptive pain

 

Mecahanistic studies on Escherichia coli DNA repair protein RadA

 

Gene expression in x-irradiated Escherichia coli

 

 

Vineet Singh, Ph.D.


vsingh@atsu.edu

 

660-626-2474

 

 

Molecular mechanisms of antibiotic and stress tolerance in Staphylococcus aureus


Molecular mechanisms of Staphylococcus aureus pathogenesis 

 

 

Melissa Stuart, Ph.D.


mstuart@atsu.edu

 

660-626-2474

 

 

Assessment of RadA-heterologous protein interactions during DNA repair


Assessment of ganglioside-protein interactions in the ocular lens

 

Production of monoclonal antibodies for use as research tools

 

 

 

 

Pharmacology Department

Yingzi Chang, M.D., Ph.D.


ychang@atsu.edu

 

660-626-2327

 

 

Mechanisms of insulin-enhanced restenosis after angioplasty in type II diabetes

 

Interaction between insulin and TNF-α on vascular injury-induced neointima formation

 

Involvement of protein tyrosine phosphatase 1B in insulin-enhanced vascular injury-induced neointima formation

 

 

Keith Elmslie, Ph.D.


kelmslie@atsu.edu

 

660-626-2384

Determine the interaction of w-conopeptides with neuronal calcium channels that are important for the treatment of neuropathic pain


Understand the molecular determinants of calcium channel gating


Examine the effects of cell membrane lipids on ion channel gating


Identify novel tri-substituted purines that specifically affect ion channel gating

 

Determine the mechanisms controlling excitability of the exercise pressor reflex to better understand how this reflex regulates the cardiovascular systems under physiological and pathophysiological conditions

 

 

David Middlemas, Ph.D.

 

dmiddlemas@atsu.edu

 

660 988 1940

Neuropharmacology of brain-derived neurotrophic factor (BDNF)

 

The role of brain derived neurotrophic factor (BDNF) and its receptor, TrkB, in drug action

 

The role of neurogenesis in anti-depressant drug action

 

 

Robert Theobald, Ph.D.

 

rtheobald@atsu.edu

 

660-626-2316

Autonomic smooth muscle pharmacology of the lower urinary tract of the cat; particularly the roles of ATP, nitric oxide, hormones, and cannabinoid agents on the regulation of cat bladder smooth muscle function

 

Effect of cannabinoids in the periaqueductal gray (PAG) area on lower urinary tract function of the cat

 

Study of the role of estrogen in the lower urinary tract, and the interaction of estrogen with other regulatory agents

 

 

 

 

Physiology Department

Robert Baer, Ph.D.


rbaer@atsu.edu

 

660-626-2322

Signal transduction in cellular adhesion and motility

 

Adhesion molecules in melanoma – migration, invasion, apoptosis

 

Signaling in vascular and vascular-like network formation (angiogenesis and vasculogenic mimicry)

 

 

George Carlson, Ph.D.

 

ccarlson@atsu.edu

 

660-626-2328

Pathogenesis of muscular dystrophy – role of Ca2+ and NFkappaB

 

Developing new treatments for muscular dystrophy using drugs that modulate cell signaling pathways

 

 

Timothy Geisbuhler, Ph.D.

 

tgeisbuhler@atsu.edu

 

660-626-2315

Impact of anoxia, estrogen, and phytoestrogens on NFkB in heart


Calcium traffic across heart cell membranes


Nucleotide metabolism in ischemic and anoxic heart cells (bioenergetics)

 

Impact of plant natural products (“nutritional supplements”) on cardiac cell metabolism

 

 

William Sexton, Ph.D.

wsexton@atsu.edu

 

660-626-2324

Determinants of oxygen delivery in the microcirculation of skeletal muscle, heart and diaphragm with emphasis on the impact of exercise training, diabetes, aging, and hypertension

Impact of peripheral vascular flow impairment on oxygen delivery and muscle function, and the role of collateral vessel formation, in health, diabetes, and exercise training

 

Role of nitric oxide in the control of oxygen delivery and utilization in contracting skeletal muscle, diaphragm and heart and interactions with disease and aging


Impact of statins on skeletal muscle function and microvascular oxygen kinetics

 

Diaphragm function in health and disease (e.g., emphysema and diabetes)

 

Molecular mechanisms of angiogenesis in skeletal muscle, diaphragm and heart

 

 

 

 

Family Medicine, Preventive Medicine and Community Health

Patricia Sexton, D.H.Ed.

psexton@atsu.edu

 

660-626-2294

Effects of plant antioxidants on differentiation and cataract formation in the ocular lens