Evidence-Based Medicine
- Overview
Show/Hide contents - What is evidence-based medicine (EBM)?
- Myths about evidence-based medicine
- The need for evidence-based medicine
- Legal information
- Making this Site Work for You
Show/Hide contents - Step 1: Construct Clinical Question
Show/Hide contents - 2 Types of Questions
Show/Hide contents - Background Questions
- Foreground Questions
Show/Hide contents - PICO Format
- Primary vs. Secondary Sources
- Another Approach: Asking Well-Formed Clinical Questions
- Assessing Your Question
- Reasoning Behind Each Piece of Your Clinical Question
- Reevaluation and Reflection
- Step 2: Locate Evidence
Show/Hide contents - Evidence Pyramid (Quality of Evidence)
Show/Hide contents - Filtered Information
Show/Hide contents - Systematic Reviews/ Meta-Analyses
- Critically-Appraised Topics (Synthesis)
- Critically-Appraised Articles (Synopsis)
- Unfiltered Information
Show/Hide contents - Randomized Controlled Trials
- Cohort Studies
- Case-Controlled Studies/Case Series and Reports
- Background Info/Expert Opinion
- Search Basics & Using PubMed (Tutorial Alongside a Frame with PubMed)
(See Search Basics & Using PubMed for details.) - Search Basics & Using PubMed
Show/Hide contents - Using the ATSU link-out to PubMed
- Brief lesson on general use of PubMed
- Using PubMed to find a systematic review
- More Advanced Searches & Using the Cochrane Library (Tutorial Alongside a Frame with the Cochrane Library)
(See More Advanced Searches & Using the Cochrane Library for details.) - More Advanced Searches & Using the Cochrane Library
Show/Hide contents - Review of Prior Lessons: Evidence Pyramid
- Purpose of the Cochrane Library
- Access the Cochrane Library through the ATSU Portal
- Search the Cochrane Library
- Advanced Search
- MeSH Search
- Search History
- Saved Searches
- Step 3: Appraise Evidence
Show/Hide contents - Diagnosis
Show/Hide contents - Diagnosis Worksheet (pdf)
- How to Appraise an Article on Diagnosis (pdf)
- Statistics for Diagnosis
Show/Hide contents - Sensitivity
- Specificity
- Likelihood Ratios
- Pre-test Probabilities/Prevalence
- Post-Test Probabilities/Predictive Values
- Therapy
Show/Hide contents - Therapy Worksheet (pdf)
- How to Appraise an Article on Therapy (pdf)
- Systematic Review of Therapy (pdf)
- How to Appraise a Systematic Review (pdf)
- Statistics for Therapy
Show/Hide contents - Control Event Rate (CER)
- Experimental Event Rate (EER)
- Number Needed to Treat (NNT)
- Absolute Risk Reduction (ARR)
- Harm/Etiology
Show/Hide contents - Harm/Etiology Woorksheet (pdf)
- How to Appraise an Article on Harm (pdf)
- Statistics for Harm/Etiology
Show/Hide contents - Number Needed to Harm (NNH)
- Absolute Risk Increase (ARI)
- Relative Risk (RR)
- Odds
- Odds Ratio (OR)
- Additional Statistical Tools and References
Show/Hide contents - Basic Statistics for Clinical Studies
Show/Hide contents - Samples and Populations
- Means and Medians
- Normal & Skewed Distributions
- Variability, Variance, & Standard Deviation
- Confidence Intervals
- p-values
- Generalized 2x2 Clinical Table
- Clinical Statistics Calculator (Spreadsheet Application)
- Step 4: Integrate Evidence into Clinical Practice
Show/Hide contents - Unique Patients with Individual Medical Needs
- Are results applicable to my patient?
- The Art of Medicine
- Integrating Patient Preferences
- Step 5: Communication & Evaluation
Show/Hide contents - Communication
Show/Hide contents - Communicate with Your Patients
- Communicate with Health Professionals
- Evaluation
Show/Hide contents - Evaluate Yourself
- How did you do?
- Basic Computer Skills
- Appraisal Worksheets
(Also see Step 3.) - PowerPoint Downloads
- More Information
Show/Hide contents
What is evidence-based medicine (EBM)?
Evidence-based medicine is defined as “the conscientious, explicit and judicious use of current best medicine in making decisions about the care of individual patients. The practice of evidence-based medicine means integrating individual clinical expertise with the best available external clinical evidence from systematic research” by David L. Sackett and his colleagues.
It has been simplified over time to be “the integration of best research evidence with clinical expertise and patient values”.
Myths about evidence-based medicine
Evidence-based medicine is not a new concept. The term evidence-based medicine was coined in 1992 by a group at McMaster University, but clinicians have always used evidence to make decisions about patient care. The evidence just may not have been the “best” evidence due to any number of reasons.
Some fear that EBM is an example of cookbook medicine, a way to cut costs of health care, or a way to keep patients from receiving the care they deserve. None of these fears is true. There will never be one recipe that fits all patients, and as stated clearly in the definitions above, EBM involves integration of clinical expertise and individual patient values. In some cases, the results of EBM may cut costs by eliminating unnecessary procedures or treatments; however there also may be situations where it is the expensive procedure or treatment that provides the best results for patients. Along that same line, practicing EBM is a way to eliminate unnecessary expenditure which in theory would allow more money to decrease the treatment and diagnostic disparities that are present in today’s society.
Many can agree with the concept of EBM but are unsure that it can be practiced in a busy clinic. In reality, it is those busy clinicians who can benefit the most from the growth of EBM. As the search engines become quicker and the number of secondary sources grows, it will be easier than ever to find the answer to a clinical question that arises from a fifteen minute office visit.
The need for evidence-based medicine
Studies suggest our need for best evidence occurs twice in every three outpatient visits and up to five times per inpatient visit. The amount of new medical information formed daily is overwhelming. It is impossible to know everything. With this rapid formation of data, familiar sources such as textbooks are out of date by the time they reach the shelf. The development of online EBM tools and journals containing pre-analyzed articles help individual providers keep current.
Most importantly, practicing evidence-based medicine leads to improved patient outcomes.
To locate a particular topic, you may choose the most appropriate options from the panels on the left or you may use the site map below. Click on the superscripted "Go there >>>" to access the information you want.
Legal information
This website is made possible by the Academic Administrative Units in Primary Care grant D54HP05442 between A.T. Still University-Kirksville College of Osteopathic Medicine and the U.S. Department of Health and Human Services, Health Resources and Services Administration, Bureau of Health Professions, Division of Medicine. Margaret A. Wilson, D.O., is the project director.
The use of the A.T. Still University (ATSU) - Evidence-Based Medicine website is intended to serve as a structured set of guidelines to improve clinical practice. A.T. Still University and its affiliates shall not be held liable for any hardships suffered or incurred as a direct or indirect result of the use or misuse of the information presented in this website, including but not limited to damage to or loss of personal property, sickness or injury from whatever source, legal entanglements, imprisonment, death, or loss of money. As with all information, the material presented in this website should be critically evaluated by the user before being implemented in a clinical setting.
Any and all information contained in this website is the property of A.T. Still University. Reposting and redistribution of this material is strictly prohibited and is illegal without explicit written approval.
The information presented on this website comes from a variety of sources, including not only official ATSU departments, but also unofficial sources and individuals. Although every effort is made to present current and accurate information, ATSU does not author or edit all of the pages presented here and therefore cannot assume responsibility for all information. The author of each web page is responsible for the content of that page and is expected to abide by organizational policies and local, state, and federal laws. To report possible copyright infringement, contact:
Susan Coon, M.A.B.C
NIH R25 Project Coordinator
Academic Affairs
A.T. Still University/Kirksville College of Osteopathic Medicine
800 W. Jefferson
Kirksville, MO 63501-1497
Phone: 660-626-2276
Fax: 660-626-2925
scoon@atsu.edu


